Acetic acid (R)-2-acetoxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester

Base Information

• Chemical Name: Acetic acid (R)-2-acetoxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester
• CAS No.: 195509-45-6
• Molecular Formula: C₁₈H₂₁F₂N₃O₅
• Molecular Weight: 397.379
• Mol file: 195509-45-6.mol

Synonyms:Acetic acid (R)-2-acetoxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester

Chemical Property of Acetic acid (R)-2-acetoxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (R)-2-acetoxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester

There total 5 articles about Acetic acid (R)-2-acetoxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.6%

acetic anhydride (108-24-7) + (R)-4-(2,4-Difluoro-phenyl)-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentane-1,4-diol (149809-38-1) → Acetic acid (R)-2-acetoxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester (195509-45-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1021/jo9709920

Reference yield: 81.0%

vinyl acetate (108-05-4,9003-20-7) + (R)-4-(2,4-Difluoro-phenyl)-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentane-1,4-diol (149809-38-1) → Acetic acid (2R,4R)-4-(2,4-difluoro-phenyl)-4-hydroxy-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentyl ester (149809-50-7) + Acetic acid (R)-2-acetoxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester (195509-45-6)

Guidance literature:

With Amano Lipase AK (Pseudomonas sp.); potassium chloride; In ethyl acetate; for 2h; Ambient temperature;

DOI:10.1021/jo9709920

Reference yield:

Hexanoic acid (R)-4-(2,4-difluoro-phenyl)-2-hexanoyloxymethyl-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester → Acetic acid (R)-2-acetoxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester (195509-45-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Amano Lipase AK (Pseudomonas sp.), aq. KCl / tetrahydrofuran / Ambient temperature

2: Amano Lipase AK (Pseudomonas sp.), aq. KCl / ethyl acetate / 2 h / Ambient temperature

With Amano Lipase AK (Pseudomonas sp.); potassium chloride; In tetrahydrofuran; ethyl acetate;

DOI:10.1021/jo9709920

upstream raw materials:

vinyl acetate

(R)-4-(2,4-Difluoro-phenyl)-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentane-1,4-diol

acetic anhydride

Butyric acid (R)-2-butyryloxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester

Downstream raw materials:

(R)-4-(2,4-Difluoro-phenyl)-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentane-1,4-diol