Butyric acid (R)-2-butyryloxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester

Base Information

• Chemical Name: Butyric acid (R)-2-butyryloxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester
• CAS No.: 195509-58-1
• Molecular Formula: C₂₂H₂₉F₂N₃O₅
• Molecular Weight: 453.486
• Mol file: 195509-58-1.mol

Synonyms:Butyric acid (R)-2-butyryloxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester

Chemical Property of Butyric acid (R)-2-butyryloxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Butyric acid (R)-2-butyryloxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester

There total 3 articles about Butyric acid (R)-2-butyryloxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.1%

butanoic acid anhydride (106-31-0) + (R)-4-(2,4-Difluoro-phenyl)-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentane-1,4-diol (149809-38-1) → Butyric acid (R)-2-butyryloxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester (195509-58-1)

Guidance literature:

With dmap; In tetrahydrofuran; for 2.5h; Ambient temperature;

DOI:10.1021/jo9709920

Reference yield:

Isobutyric acid (R)-4-(2,4-difluoro-phenyl)-4-hydroxy-2-isobutyryloxymethyl-5-[1,2,4]triazol-1-yl-pentyl ester → Butyric acid (R)-2-butyryloxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester (195509-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Amano Lipase AK (Pseudomonas sp.), aq. KCl / tetrahydrofuran / Ambient temperature

2: 94.1 percent / DMAP / tetrahydrofuran / 2.5 h / Ambient temperature

With dmap; Amano Lipase AK (Pseudomonas sp.); potassium chloride; In tetrahydrofuran;

DOI:10.1021/jo9709920

Reference yield:

Hexanoic acid (R)-4-(2,4-difluoro-phenyl)-2-hexanoyloxymethyl-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester → Butyric acid (R)-2-butyryloxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester (195509-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Amano Lipase AK (Pseudomonas sp.), aq. KCl / tetrahydrofuran / Ambient temperature

2: 94.1 percent / DMAP / tetrahydrofuran / 2.5 h / Ambient temperature

With dmap; Amano Lipase AK (Pseudomonas sp.); potassium chloride; In tetrahydrofuran;

DOI:10.1021/jo9709920

upstream raw materials:

butanoic acid anhydride

(R)-4-(2,4-Difluoro-phenyl)-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentane-1,4-diol

Downstream raw materials:

(R)-4-(2,4-Difluoro-phenyl)-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentane-1,4-diol

Acetic acid (2R,4R)-4-(2,4-difluoro-phenyl)-4-hydroxy-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentyl ester

Acetic acid (R)-2-acetoxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester