Acetic acid (2R,4R)-4-(2,4-difluoro-phenyl)-4-hydroxy-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentyl ester

Base Information

• Chemical Name: Acetic acid (2R,4R)-4-(2,4-difluoro-phenyl)-4-hydroxy-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentyl ester
• CAS No.: 149809-50-7
• Molecular Formula: C₁₆H₁₉F₂N₃O₄
• Molecular Weight: 355.341

Synonyms:Acetic acid (2R,4R)-4-(2,4-difluoro-phenyl)-4-hydroxy-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentyl ester

Chemical Property of Acetic acid (2R,4R)-4-(2,4-difluoro-phenyl)-4-hydroxy-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Acetic acid (2R,4R)-4-(2,4-difluoro-phenyl)-4-hydroxy-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentyl ester

There total 6 articles about Acetic acid (2R,4R)-4-(2,4-difluoro-phenyl)-4-hydroxy-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

vinyl acetate (108-05-4,9003-20-7) + (R)-4-(2,4-Difluoro-phenyl)-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentane-1,4-diol (149809-38-1) → Acetic acid (2R,4R)-4-(2,4-difluoro-phenyl)-4-hydroxy-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentyl ester (149809-50-7) + Acetic acid (R)-2-acetoxymethyl-4-(2,4-difluoro-phenyl)-4-hydroxy-5-[1,2,4]triazol-1-yl-pentyl ester (195509-45-6)

Guidance literature:

With Amano Lipase AK (Pseudomonas sp.); potassium chloride; In ethyl acetate; for 2h; Ambient temperature;

DOI:10.1021/jo9709920

Reference yield: 78.0%

acetic acid methyl ester (79-20-9) + (R)-4-(2,4-Difluoro-phenyl)-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentane-1,4-diol (149809-38-1) → Acetic acid (2R,4R)-4-(2,4-difluoro-phenyl)-4-hydroxy-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentyl ester (149809-50-7)

Guidance literature:

With porcine pancreatic lipase; for 48h; Ambient temperature;

DOI:10.1016/0040-4039(94)88071-9

Reference yield: 57.0%

ethyl acetate (141-78-6) + (R)-4-(2,4-Difluoro-phenyl)-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentane-1,4-diol (149809-38-1) → Acetic acid (2R,4R)-4-(2,4-difluoro-phenyl)-4-hydroxy-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentyl ester (149809-50-7)

Guidance literature:

With porcine pancreatic lipase; for 24h; Ambient temperature;

DOI:10.1016/0040-4039(94)88071-9

upstream raw materials:

acetic acid methyl ester

(R)-4-(2,4-Difluoro-phenyl)-2-hydroxymethyl-5-[1,2,4]triazol-1-yl-pentane-1,4-diol

ethyl acetate

vinyl acetate

Downstream raw materials:

((3R,5R)-5-((1H-1,2,4-triazole-1-yl) methyl)-5-(2,4-difluorophenyl) tetrahydrofuran-3-yl)methanol

1-[(2R,4S)-2-(2,4-Difluoro-phenyl)-4-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-2-ylmethyl]-1H-[1,2,4]triazole

(2R-cis)-2-(2,4-difluorophenyl)-4-[[(4-methylphenyl)sulfonyloxy]methyl]-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

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