6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-1,3-di(methoxymethyl)-5-methyl-pyrimidine-2,4-dione

Base Information

Chemical Name:6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-1,3-di(methoxymethyl)-5-methyl-pyrimidine-2,4-dione
CAS No.:1311145-52-4
Molecular Formula:C₂₇H₃₄N₂O₆
Molecular Weight:482.577
Hs Code.:

Synonyms:6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-1,3-di(methoxymethyl)-5-methyl-pyrimidine-2,4-dione

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Chemical Property of 6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-1,3-di(methoxymethyl)-5-methyl-pyrimidine-2,4-dione

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Technology Process of 6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-1,3-di(methoxymethyl)-5-methyl-pyrimidine-2,4-dione

There total 15 articles about 6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-1,3-di(methoxymethyl)-5-methyl-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.5%

: 1311145-51-3
6-[3-(benzyloxy)-2-(benzyloxymethyl)propyl]-5-methylpyrimidine-2,4-dione

: 107-30-2
chloromethyl methyl ether

: 1311145-53-5
6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-1-methoxymethyl-5-methylpyrimidine-2,4-dione

: 1311145-55-7
6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-3-methoxymethyl-5-methylpyrimidine-2,4-dione

: 1311145-52-4
6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-1,3-di(methoxymethyl)-5-methyl-pyrimidine-2,4-dione

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at -15 - 20 ℃;
DOI:10.3390/molecules16065113

Reference yield: 2.9%

: 1311145-51-3
6-[3-(benzyloxy)-2-(benzyloxymethyl)propyl]-5-methylpyrimidine-2,4-dione

: 107-30-2
chloromethyl methyl ether

: 1311145-53-5
6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-1-methoxymethyl-5-methylpyrimidine-2,4-dione

: 1311145-52-4
6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-1,3-di(methoxymethyl)-5-methyl-pyrimidine-2,4-dione

Guidance literature:: 6-[3-(benzyloxy)-2-(benzyloxymethyl)propyl]-5-methylpyrimidine-2,4-dione; With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; for 1h; Inert atmosphere; Reflux;

chloromethyl methyl ether; at 20 ℃;
DOI:10.3390/molecules16065113

Reference yield:

: 1780-32-1
2,4-dichloro-5,6-dimethylpyrimidine

: 1311145-52-4
6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-1,3-di(methoxymethyl)-5-methyl-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate

2.1: lithium diisopropyl amide / tetrahydrofuran / -55 °C

3.1: dmap / acetonitrile

4.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene

5.1: acetyl chloride / 20 °C / Reflux

5.2: 20 °C

6.1: ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane / 1 h / Inert atmosphere; Reflux

6.2: 20 °C

With dmap; ammonium sulfate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium methylate; acetyl chloride; 1,1,1,3,3,3-hexamethyl-disilazane; lithium diisopropyl amide; In tetrahydrofuran; toluene; acetonitrile; 4.1: Barton-McCombie deoxygenation;
DOI:10.3390/molecules16065113