6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-5-methyl-2,4-dimethoxypyrimidine

Base Information

Chemical Name:6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-5-methyl-2,4-dimethoxypyrimidine
CAS No.:914824-82-1
Molecular Formula:C₂₅H₃₀N₂O₄
Molecular Weight:422.524
Hs Code.:

Synonyms:6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-5-methyl-2,4-dimethoxypyrimidine

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Chemical Property of 6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-5-methyl-2,4-dimethoxypyrimidine

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Technology Process of 6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-5-methyl-2,4-dimethoxypyrimidine

There total 8 articles about 6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-5-methyl-2,4-dimethoxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 914824-72-9
6-[(3-benzyloxy-2-benzyIoxymethyl-2-methyloxalyI)propyl]-2,4-dimethoxy-5-methylpyrimidine

: 914824-82-1
6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-5-methyl-2,4-dimethoxypyrimidine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 110 ℃; for 3h; Inert atmosphere;
DOI:10.1080/15257770.2011.581258

Reference yield:

: 139871-31-1
6-<<2-<1,3-bis(benzyloxy)-2-hydroxypropyl>>methyl>-2,4-dimethoxy-5-methylpyrimidine

: 914824-82-1
6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-5-methyl-2,4-dimethoxypyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / acetonitrile

2: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; acetonitrile; 2: Barton-McCombie deoxygenation;
DOI:10.3390/molecules16065113

Reference yield:

: 77356-14-0
1,3-dibenzyloxy-2-propanone

: 914824-82-1
6-[(3-benzyloxy)-2-(benzyloxymethyl)propyl]-5-methyl-2,4-dimethoxypyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium diisopropyl amide / tetrahydrofuran / -55 °C

2: dmap / acetonitrile

3: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; lithium diisopropyl amide; In tetrahydrofuran; toluene; acetonitrile; 3: Barton-McCombie deoxygenation;
DOI:10.3390/molecules16065113