1780-32-1

Basic information

• Product Name: 2,4-Dichloro-5,6-dimethylpyrimidine
• Synonyms: 2,4-Dichloro-5,6-dimethylpyrimidine;PyriMidine, 2,4-dichloro-5,6-diMethyl-
• CAS NO: 1780-32-1
• Molecular Formula: C₆H₆Cl₂N₂
• Molecular Weight: 177.03
• Product Categories: pharmacetical;pyrimidine;Heterocycle-Pyrimidine series
• Mol File: 1780-32-1.mol
• Article Data: 15

Chemical Properties

• Melting Point: 70-71 °C(Solv: ethanol (64-17-5))
• Boiling Point: 245.3 °C at 760 mmHg
• Flash Point: 125.9 °C
• Appearance: /
• Density: 1.337 g/cm³
• Vapor Pressure: 0.0453mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.72±0.39(Predicted)
• CAS DataBase Reference: 2,4-Dichloro-5,6-dimethylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichloro-5,6-dimethylpyrimidine(1780-32-1)
• EPA Substance Registry System: 2,4-Dichloro-5,6-dimethylpyrimidine(1780-32-1)

Safety Data

• Hazardous Substances Data: 1780-32-1(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-5,6-dimethylpyrimidine is a chemical compound with the molecular formula C6H6Cl2N2. It is a pyrimidine derivative with two chlorine atoms and two methyl groups attached to the pyrimidine ring. 2,4-Dichloro-5,6-dimethylpyrimidine is used as a building block in organic synthesis and as a precursor in the manufacturing of various pharmaceuticals and agricultural chemicals. It is also used as an intermediate in the production of fungicides and herbicides. 2,4-Dichloro-5,6-dimethylpyrimidine is flammable and may cause irritation to the eyes, skin, and respiratory system upon exposure. Therefore, proper safety measures should be taken when handling this compound.

InChI:InChI=1/C6H6Cl2N2/c1-3-4(2)9-6(8)10-5(3)7/h1-2H3

Upstream product

• 26305-13-5 5,6-dimethyluracil 
• 121-69-7 N,N-dimethyl-aniline 
• 26305-13-5 5,6-dimethyl-2,4-dihydroxy pyrimidine 
• 28456-54-4 5,6-dimethyl-2-thiouracil 
• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 10025-87-3 trichlorophosphate 

Downstream Products

• 120129-83-1 2,4-dimethoxy-5,6-dimethylpyrimidine 
• 694-81-5 4,5-dimethylpyrimidine 
• 34916-78-4 5,6-dimethyl-3H-pyrimidin-4-one 
• 14394-61-7 2-amino-4-chloro-5,6-dimethyl-pyrimidine 
• 14394-62-8 2-chloro-5,6-dimethyl-pyrimidin-4-ylamine 
• 7132-61-8 2,4-Diamino-5,6-dimethylpyrimidin 
• 1312992-32-7 6-[3-(benzyloxy)-2-(benzyloxymethyl)propyl]-4-methoxy-1,5-dimethylpyrimidin-2(1H)-one 
• 1450808-81-7 2-chloro-N-cyclohexyl-5,6-dimethylpyrimidin-4-amine 
• 1450809-14-9 2-chloro-N-(4,4-difluorocyclohexyl)-5,6-dimethylpyrimidin-4-amine 

Relevant articles and documents

Indole pyrimidine compound as well as synthesis method and application thereof

The invention discloses an indole pyrimidine compound, the structural formula of which is as shown in formula (I): wherein L is selected from any one of H, OH, halogen, alkoxy, halogenated alkyl, alkyl, aryl and pyridine, Q is O, S or NH, X is NH or -CONH, n is a natural number, R is N(CH3)2 or T is selected from at least one of H, OH, halogen, alkoxy, halogenated alkyl, alkyl, aryl and pyridine. The indole pyrimidine compound provided by the invention can effectively inhibit adipocyte differentiation, and has a better lipid-lowering effect.

BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS

Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.

POTENT DUAL BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS

Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects, disclosed are compounds of Formula I-IV.