(2S,4R)-4-[(S)-Methoxycarbonyl-(toluene-4-sulfonylamino)-methyl]-5-oxo-pyrrolidine-2-carboxylic acid

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Chemical Name:(2S,4R)-4-[(S)-Methoxycarbonyl-(toluene-4-sulfonylamino)-methyl]-5-oxo-pyrrolidine-2-carboxylic acid
CAS No.:1027946-98-0
Molecular Formula:C₁₅H₁₈N₂O₇S
Molecular Weight:370.383
Hs Code.:

Synonyms:(2S,4R)-4-[(S)-Methoxycarbonyl-(toluene-4-sulfonylamino)-methyl]-5-oxo-pyrrolidine-2-carboxylic acid

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Chemical Property of (2S,4R)-4-[(S)-Methoxycarbonyl-(toluene-4-sulfonylamino)-methyl]-5-oxo-pyrrolidine-2-carboxylic acid

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Technology Process of (2S,4R)-4-[(S)-Methoxycarbonyl-(toluene-4-sulfonylamino)-methyl]-5-oxo-pyrrolidine-2-carboxylic acid

There total 6 articles about (2S,4R)-4-[(S)-Methoxycarbonyl-(toluene-4-sulfonylamino)-methyl]-5-oxo-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 637019-61-5
(2S,4R,1'S)-2-hydroxymethyl-4-(methoxycarbonyl-N-tosylaminomethyl)-5-oxopyrrolidine

: 1027946-98-0
(2S,4R)-4-[(S)-Methoxycarbonyl-(toluene-4-sulfonylamino)-methyl]-5-oxo-pyrrolidine-2-carboxylic acid

Guidance literature:: (2S,4R,1'S)-2-hydroxymethyl-4-(methoxycarbonyl-N-tosylaminomethyl)-5-oxopyrrolidine; With sodium periodate; In tetrachloromethane; acetonitrile; at 20 ℃; for 0.166667h;

ruthenium trichloride; In tetrachloromethane; acetonitrile; at 20 ℃; Further stages.;
DOI:10.1039/b303924b

Reference yield:

: 13707-47-6
2-furaldehyde tosylimine

: 1027946-98-0
(2S,4R)-4-[(S)-Methoxycarbonyl-(toluene-4-sulfonylamino)-methyl]-5-oxo-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 76 percent / tetrahydrofuran / 1 h

2.1: 27 percent / NaH / tetrahydrofuran / 5 h / Heating

3.1: aq. NaIO₄ / RuCl₃*H₂O / CCl₄; acetonitrile / 4 h

4.1: 43 mg / tetrahydrofuran; diethyl ether / 0.5 h

5.1: 45 percent / CF₃COOH / CH₂Cl₂ / 1 h / 20 °C

6.1: aq. NaIO₄ / CCl₄; acetonitrile / 0.17 h / 20 °C

6.2: RuCl₃*H₂O / CCl₄; acetonitrile / 20 °C

With sodium periodate; sodium hydride; trifluoroacetic acid; lithium diisopropyl amide; ruthenium trichloride; In tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; dichloromethane; acetonitrile;
DOI:10.1039/b303924b

Reference yield:

: 637019-59-1
(2R,5S,7R,1'S)-7-(N-tosylaminofuran-2-ylmethyl)-8-oxo-2-phenyl-2-methyl-1-aza-3-oxabicyclo[3.3.0]octane

: 1027946-98-0
(2S,4R)-4-[(S)-Methoxycarbonyl-(toluene-4-sulfonylamino)-methyl]-5-oxo-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. NaIO₄ / RuCl₃*H₂O / CCl₄; acetonitrile / 4 h

2.1: 43 mg / tetrahydrofuran; diethyl ether / 0.5 h

3.1: 45 percent / CF₃COOH / CH₂Cl₂ / 1 h / 20 °C

4.1: aq. NaIO₄ / CCl₄; acetonitrile / 0.17 h / 20 °C

4.2: RuCl₃*H₂O / CCl₄; acetonitrile / 20 °C

With sodium periodate; trifluoroacetic acid; ruthenium trichloride; In tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1039/b303924b