(2S,4R,1'S)-2-hydroxymethyl-4-(methoxycarbonyl-N-tosylaminomethyl)-5-oxopyrrolidine

Base Information

Chemical Name:(2S,4R,1'S)-2-hydroxymethyl-4-(methoxycarbonyl-N-tosylaminomethyl)-5-oxopyrrolidine
CAS No.:637019-61-5
Molecular Formula:C₁₅H₂₀N₂O₆S
Molecular Weight:356.4
Hs Code.:

Synonyms:(2S,4R,1'S)-2-hydroxymethyl-4-(methoxycarbonyl-N-tosylaminomethyl)-5-oxopyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R,1'S)-2-hydroxymethyl-4-(methoxycarbonyl-N-tosylaminomethyl)-5-oxopyrrolidine

Chemical Property:

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Technology Process of (2S,4R,1'S)-2-hydroxymethyl-4-(methoxycarbonyl-N-tosylaminomethyl)-5-oxopyrrolidine

There total 5 articles about (2S,4R,1'S)-2-hydroxymethyl-4-(methoxycarbonyl-N-tosylaminomethyl)-5-oxopyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 637019-60-4
(2R,5S,7R,1'S)-7-(methoxycarbonyl-N-tosylmethyl)-8-oxo-2-phenyl-1-aza-3-oxabicyclo[3.3.0]octane

: 637019-61-5
(2S,4R,1'S)-2-hydroxymethyl-4-(methoxycarbonyl-N-tosylaminomethyl)-5-oxopyrrolidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1039/b303924b

Reference yield:

: 13707-47-6
2-furaldehyde tosylimine

: 637019-61-5
(2S,4R,1'S)-2-hydroxymethyl-4-(methoxycarbonyl-N-tosylaminomethyl)-5-oxopyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 76 percent / tetrahydrofuran / 1 h

2.1: 27 percent / NaH / tetrahydrofuran / 5 h / Heating

3.1: aq. NaIO₄ / RuCl₃*H₂O / CCl₄; acetonitrile / 4 h

4.1: 43 mg / tetrahydrofuran; diethyl ether / 0.5 h

5.1: 45 percent / CF₃COOH / CH₂Cl₂ / 1 h / 20 °C

With sodium periodate; sodium hydride; trifluoroacetic acid; lithium diisopropyl amide; ruthenium trichloride; In tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; dichloromethane; acetonitrile;
DOI:10.1039/b303924b

Reference yield:

: 637019-59-1
(2R,5S,7R,1'S)-7-(N-tosylaminofuran-2-ylmethyl)-8-oxo-2-phenyl-2-methyl-1-aza-3-oxabicyclo[3.3.0]octane

: 637019-61-5
(2S,4R,1'S)-2-hydroxymethyl-4-(methoxycarbonyl-N-tosylaminomethyl)-5-oxopyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaIO₄ / RuCl₃*H₂O / CCl₄; acetonitrile / 4 h

2: 43 mg / tetrahydrofuran; diethyl ether / 0.5 h

3: 45 percent / CF₃COOH / CH₂Cl₂ / 1 h / 20 °C

With sodium periodate; trifluoroacetic acid; ruthenium trichloride; In tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1039/b303924b