ethyl-4-{3-[2-(tert-butoxycarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminosulfonyl}butanoate

Base Information

Chemical Name:ethyl-4-{3-[2-(tert-butoxycarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminosulfonyl}butanoate
CAS No.:197707-86-1
Molecular Formula:C₃₂H₄₅NO₈S
Molecular Weight:603.777
Hs Code.:

Synonyms:ethyl-4-{3-[2-(tert-butoxycarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminosulfonyl}butanoate

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Chemical Property of ethyl-4-{3-[2-(tert-butoxycarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminosulfonyl}butanoate

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Technology Process of ethyl-4-{3-[2-(tert-butoxycarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminosulfonyl}butanoate

There total 13 articles about ethyl-4-{3-[2-(tert-butoxycarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminosulfonyl}butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 319452-60-3
4-Chlorosulfonyl-butyric acid ethyl ester

: 134577-85-8
t-Butyl 3-[1-[6-(4-methoxyphenyl)hex-5E-enyl]oxy-4-aminobenzen-2-yl]propionate

: 197707-86-1
ethyl-4-{3-[2-(tert-butoxycarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminosulfonyl}butanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/S0968-0896(97)00089-8

Reference yield:

: 502-44-3,24980-41-4,80137-66-2
hexahydro-2H-oxepin-2-one

: 197707-86-1
ethyl-4-{3-[2-(tert-butoxycarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminosulfonyl}butanoate

Guidance literature:: Multi-step reaction with 9 steps

1: conc. sulfuric acid / 1 h / Heating

2: AlCl₃ / 1,2-dichloro-ethane / 2.5 h / 15 °C

3: 5N aq. NaOH / methanol / 1 h / 25 °C

4: NaBH₄ / methanol / 1 h / 25 - 65 °C

5: 73 percent / KCl / dimethylsulfoxide / 4 h / 170 °C

6: 92 percent / triethylamine / CH₂Cl₂ / 1 h

7: 1.) NaH / 1.) DMF, a) from 0 deg C to 25 deg C, b) 25 deg C, 30 min, 2.) DMF, 60 deg C, 2 h

8: 78 percent / aq. K₂CO₃ / methanol / 16 h / 25 °C

9: 78 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

With sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; sulfuric acid; potassium chloride; sodium hydride; potassium carbonate; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1016/S0968-0896(97)00089-8

Reference yield:

: 128577-60-6
(5E)-6-(4-Methoxyphenyl)-5-hexen-1-ol

: 197707-86-1
ethyl-4-{3-[2-(tert-butoxycarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminosulfonyl}butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / triethylamine / CH₂Cl₂ / 1 h

2: 1.) NaH / 1.) DMF, a) from 0 deg C to 25 deg C, b) 25 deg C, 30 min, 2.) DMF, 60 deg C, 2 h

3: 78 percent / aq. K₂CO₃ / methanol / 16 h / 25 °C

4: 78 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

With sodium hydride; potassium carbonate; triethylamine; In methanol; dichloromethane;
DOI:10.1016/S0968-0896(97)00089-8