t-Butyl 3-[1-[6-(4-methoxyphenyl)hex-5E-enyl]oxy-4-aminobenzen-2-yl]propionate

Base Information

Chemical Name:t-Butyl 3-[1-[6-(4-methoxyphenyl)hex-5E-enyl]oxy-4-aminobenzen-2-yl]propionate
CAS No.:134577-85-8
Molecular Formula:C₂₆H₃₅NO₄
Molecular Weight:425.568
Hs Code.:

Synonyms:t-Butyl 3-[1-[6-(4-methoxyphenyl)hex-5E-enyl]oxy-4-aminobenzen-2-yl]propionate

Suppliers and Price of t-Butyl 3-[1-[6-(4-methoxyphenyl)hex-5E-enyl]oxy-4-aminobenzen-2-yl]propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of t-Butyl 3-[1-[6-(4-methoxyphenyl)hex-5E-enyl]oxy-4-aminobenzen-2-yl]propionate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of t-Butyl 3-[1-[6-(4-methoxyphenyl)hex-5E-enyl]oxy-4-aminobenzen-2-yl]propionate

There total 13 articles about t-Butyl 3-[1-[6-(4-methoxyphenyl)hex-5E-enyl]oxy-4-aminobenzen-2-yl]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 197707-82-7
tert-butyl-3-{2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]-5-(trifluoroacetylamino)phenyl}propanoate

: 134577-85-8
t-Butyl 3-[1-[6-(4-methoxyphenyl)hex-5E-enyl]oxy-4-aminobenzen-2-yl]propionate

Guidance literature:: With potassium carbonate; In methanol; at 25 ℃; for 16h;
DOI:10.1016/S0968-0896(97)00089-8

Reference yield:

: 502-44-3,24980-41-4,80137-66-2
hexahydro-2H-oxepin-2-one

: 134577-85-8
t-Butyl 3-[1-[6-(4-methoxyphenyl)hex-5E-enyl]oxy-4-aminobenzen-2-yl]propionate

Guidance literature:: Multi-step reaction with 8 steps

1: conc. sulfuric acid / 1 h / Heating

2: AlCl₃ / 1,2-dichloro-ethane / 2.5 h / 15 °C

3: 5N aq. NaOH / methanol / 1 h / 25 °C

4: NaBH₄ / methanol / 1 h / 25 - 65 °C

5: 73 percent / KCl / dimethylsulfoxide / 4 h / 170 °C

6: 92 percent / triethylamine / CH₂Cl₂ / 1 h

7: 1.) NaH / 1.) DMF, a) from 0 deg C to 25 deg C, b) 25 deg C, 30 min, 2.) DMF, 60 deg C, 2 h

8: 78 percent / aq. K₂CO₃ / methanol / 16 h / 25 °C

With sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; sulfuric acid; potassium chloride; sodium hydride; potassium carbonate; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1016/S0968-0896(97)00089-8

Reference yield:

: 128577-60-6
(5E)-6-(4-Methoxyphenyl)-5-hexen-1-ol

: 134577-85-8
t-Butyl 3-[1-[6-(4-methoxyphenyl)hex-5E-enyl]oxy-4-aminobenzen-2-yl]propionate

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / triethylamine / CH₂Cl₂ / 1 h

2: 1.) NaH / 1.) DMF, a) from 0 deg C to 25 deg C, b) 25 deg C, 30 min, 2.) DMF, 60 deg C, 2 h

3: 78 percent / aq. K₂CO₃ / methanol / 16 h / 25 °C

With sodium hydride; potassium carbonate; triethylamine; In methanol; dichloromethane;
DOI:10.1016/S0968-0896(97)00089-8