128577-60-6

Upstream product

• 81077-29-4 (E)-6-(4-methoxyphenyl)pent-5-enoic acid 
• 128599-33-7 4-(6-hydroxy-hex-1-ynyl)-methoxybenzene 
• 696-62-8 para-iodoanisole 
• 928-90-5 5-hexyl-1-ol 
• 83085-84-1 <5-(acetyloxy)pentyl>triphenylphosphonium bromide 
• 123-11-5 4-methoxy-benzaldehyde 
• 34626-51-2 5-bromopentan-1-ol 
• 15848-22-3 5-bromo-1-pentanyl acetate 
• 1266606-65-8 6-(4-methoxyphenyl)hex-5-enyl acetate 
• 2067-33-6 5-bromopentanoic acid 
• 100-66-3 methoxybenzene 
• 129887-45-2 ethyl 6-(p-methoxyphenyl)-6-hydroxyhexanoate 
• 42916-80-3 ethyl 6-(4-methoxyphenyl)-6-oxohexanoate 
• 626-86-8 adipinic acid monoethyl ester 

Downstream Products

• 13664-86-3 trans-6-(p-Methoxy-phenyl)-hexen-⁽⁵⁾-yl-⁽¹⁾-p-brom-benzolsulfonat 
• 117423-74-2 LY223982 
• 128577-80-0 3-{3-(2-Ethoxycarbonyl-ethyl)-4-[(E)-6-(4-methoxy-phenyl)-hex-5-enyloxy]-benzoyl}-benzoic acid ethyl ester 
• 129887-63-4 (Z)-6-(p-methoxyphenyl)-5-hexenyl 9-phenanthrenecarboxylate 
• 197707-75-8 methyl-3-{5-[3-(mmethoxycarbonyl)benzoylamino]-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoate 
• 197707-86-1 ethyl-4-{3-[2-(tert-butoxycarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminosulfonyl}butanoate 
• 197707-76-9 methyl-4-{3-(2-ethoxycarbonylethyl)-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminocarbonyl}butanoate 
• 197707-80-5 methyl 4-{3-[2-(dimethylaminocarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminocarbonyl}butanoate 
• 134577-71-2 t-Butyl 3-[1-[6-(4-methoxyphenyl)hex-5E-enyl]oxy-4-(4-methoxycarbonylbutanamido)benzen-2-yl]propionate 

Relevant academic research and scientific papers

Convenient approach for the synthesis of ONO-LB-457, a potent leukotriene B4 receptor antagonist

This study reports a new approach for the synthesis of 5-[2-(2-carboxyethyl)-3-[6-(4-methoxyphenyl)-(5E)-hexen-1-yloxy]phenoxy]pentanoic acid V (ONO-LB-457), previously described by Konno and col. and which is considered a highly potent and orally active

Acid-Promoted Cascade Cyclization to Produce 2-(4′-Alkoxyaryl)-3,4-Fused Tricyclic Dihydrobenzopyrans via a Vinylidene para-Quinone Methide Intermediate

We developed a novel method for synthesizing 2-(4-hydroxyaryl)-3,4-fused tricyclic dihydrobenzopyrans with 2,3-syn and 3,4-syn motif based on the acid-promoted cascade cyclization via vinylidene para-quinone methide intermediates. Using easily prepared li

Electronically Mismatched Cycloaddition Reactions via First-Row Transition Metal, Iron(III)-Polypyridyl Complex

The iron(III)-polypyridyl complex and its derivatives showed sufficient oxidizing potential to act as a one-electron oxidant, producing radical cations from olefins and promoting the efficient radical cation [2 + 2] and [2 + 4] cycloaddition reactions. Subsequent chain propagation afforded trisubstituted cyclobutane or cyclohexene derivatives, and this facile route enables the replacement of rare metals with sustainable, green, and inexpensive iron in radical cation cycloadditions.

Trisubstituted benzene leukotriene B4 receptor antagonists: Synthesis and structure-activity relationships

A series of trisubstituted benzenes which demonstrate leukotriene B4 (LTB4, 1) receptor affinity was prepared. Previous trisubstituted benzenes from our laboratory showed high affinity to the LTB4 receptor but demonstrated

LEUKOTRIENE-B4 ANTAGONIST COMPOUNDS AND THEIR USE AS PHARMACEUTICAL AGENTS

1. Leukotriene-B 4 antagonists of formula I STR1 are described, in which X is a CH 2 group or an oxygen atom,Y is C. sub.1-C 4-alkoxy or--S(O) p--C 1-C 4-alkyl,p is 0, 1 or 2Z is a hydrogen atom or the radical A-B-COOH with A being a hydroxymethylene group or a carbonyl group and B being an alkylene group with 1-6 atoms in the chain or a radical STR2 with the exception that B cannot mean the radical STR3 if X is a CH. sub.2 group, R 1 is the radical OH,--O--(C 1--C 4)-alkyl,--O--(C 3-C 6)-cycloalkyl,--O--(C 7-C. sub.12)-aralkyl or the radical NHR 4 with R 4 being hydrogen, (C. sub.1-C 4)-alkyl, (C 3-C 6)-cycloalkyl, C 6-C 10-aryl or (C 7-C 12)-aralkyl as well as their salts with physiologically compatible bases and their cyclodextrin clathrates, process for their production and their use as pharmaceutical agents.

Benzophenone Dicarboxylic Acid Antagonists of Leukotriene B4. 2. Structure-Activity Relationships of the Lipophilic Side Chain

A series of lipophilic benzophenone dicarboxylic acid derivatives were found to inhibit the binding of the potent chemotoxin leukotriene B4 (LTB4) to its receptor on intact human neutrophils.Activity at the LTB4 receptor was determined by using a 3H>LTB4-binding assay.The structure-activity relationship for the lipophilic side chain was systematically investigated.Compounds with n-alkyl side chains of varying lengths were prepared and tested.Best inhibition of 3H>LTB4 binding was observed with the n-decyl derivative.Analogues with alkyl chains terminated with an aromatic ring showed improved activity.The 6-phenylhexyl side chain was optimal.Substitution on the terminal aromatic ring was also evaluated.Methoxyl, methylsulfinyl, and methyl substituents greatly enhanced the activity of the compound.For a given substituent, the para isomer had the best activity.Thus the nature of the lipophilic side chain can greatly influence the ability of the compounds to inhibit the binding of LTB4 to its receptor on intact human neutrophils.The most active compound from this series, 84 (LY223982), bound to the LTB4 receptor with the affinity approaching that of the agonist.