N₄-(3-fluorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₄-(3-fluorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine
• CAS No.: 1126602-53-6
• Molecular Formula: C₁₇H₁₃FN₄
• Molecular Weight: 292.315
• Mol file: 1126602-53-6.mol

Synonyms:N₄-(3-fluorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine

Chemical Property of N₄-(3-fluorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₄-(3-fluorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine

There total 5 articles about N₄-(3-fluorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

meta-fluoroaniline (372-19-0) + 2-amino-9H-indeno[2,1-d]pyrimidin-4-yl 4-nitrobenzenesulfonate (1126602-50-3) → N4-(3-fluorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine (1126602-53-6)

Guidance literature:

In 1,4-dioxane; Reflux;

DOI:10.1016/j.bmc.2012.05.068

Reference yield: 13.0%

→ N4-(3-fluorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine (1126602-53-6)

Guidance literature:

Reference yield:

ethyl 2-[2-(2-ethoxy-2-oxoethyl)phenyl]acetate (17532-66-0) → N4-(3-fluorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine (1126602-53-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium / toluene / 4 h / Reflux

2: potassium tert-butylate / tert-butyl alcohol / 4 h / 150 °C / Microwave irradiation

3: dmap; triethylamine / dichloromethane / 4 h / 20 °C

4: 1,4-dioxane / Reflux

With dmap; potassium tert-butylate; sodium; triethylamine; In 1,4-dioxane; dichloromethane; toluene; tert-butyl alcohol; 1: Dieckmann reaction;

DOI:10.1016/j.bmc.2012.05.068

upstream raw materials:

meta-fluoroaniline

2-amino-9H-indeno[2,1-d]pyrimidin-4-yl 4-nitrobenzenesulfonate

2-amino-3H,4H,9H-indeno[2,1-d]pyrimidin-4-one

ethyl 2-[2-(2-ethoxy-2-oxoethyl)phenyl]acetate