tert-butyl 3(S)-[1(S)-benzyloxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

Base Information

Chemical Name:tert-butyl 3(S)-[1(S)-benzyloxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate
CAS No.:99198-13-7
Molecular Formula:C₃₂H₄₂N₂O₆
Molecular Weight:550.695
Hs Code.:

Synonyms:tert-butyl 3(S)-[1(S)-benzyloxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

Suppliers and Price of tert-butyl 3(S)-[1(S)-benzyloxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 3(S)-[1(S)-benzyloxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 3(S)-[1(S)-benzyloxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

There total 15 articles about tert-butyl 3(S)-[1(S)-benzyloxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 100-39-0
benzyl bromide

: 99198-12-6
tert-butyl (S)-3-<(S)-1-carboxy-3-cyclohexylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

: 99198-13-7
tert-butyl 3(S)-[1(S)-benzyloxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1248/cpb.34.1128

Reference yield:

: 107-59-5
tert-Butyl chloroacetate

: 99198-13-7
tert-butyl 3(S)-[1(S)-benzyloxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / K₂CO₃, KI / dimethylformamide / Ambient temperature

2: 67 percent / H₂ / 5 percent Pd-C / methanol / Ambient temperature

3: 20 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

4: 85 percent / 1 N NaOH / H₂O / 2 h / Ambient temperature

5: 84 percent / NaHCO₃ / dimethylformamide / Ambient temperature

With sodium hydroxide; 4 A molecular sieve; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate; potassium iodide; palladium on activated charcoal; In methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128

Reference yield:

: 6048-09-5
3-cyclohexylacrylic acid ethyl ester

: 99198-13-7
tert-butyl 3(S)-[1(S)-benzyloxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / H₂ / 10 percent Pd-C / ethanol / Ambient temperature

2: 1) NaOEt; 2) H₂SO₄, NaCl / 1) EtOH, 70 deg C, 60 min; 2) DMSO, 140 deg C, 2.5 h

3: 20 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

4: 85 percent / 1 N NaOH / H₂O / 2 h / Ambient temperature

5: 84 percent / NaHCO₃ / dimethylformamide / Ambient temperature

With sodium hydroxide; 4 A molecular sieve; sulfuric acid; hydrogen; sodium ethanolate; sodium cyanoborohydride; sodium hydrogencarbonate; sodium chloride; palladium on activated charcoal; In ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128