(7S,11R)-2-Benzyl-11-(tert-butyl-dimethyl-silanyloxy)-2-aza-spiro[5.5]undecan-7-ol

Base Information

Chemical Name:(7S,11R)-2-Benzyl-11-(tert-butyl-dimethyl-silanyloxy)-2-aza-spiro[5.5]undecan-7-ol
CAS No.:120186-08-5
Molecular Formula:C₂₃H₃₉NO₂Si
Molecular Weight:389.654
Hs Code.:

Synonyms:(7S,11R)-2-Benzyl-11-(tert-butyl-dimethyl-silanyloxy)-2-aza-spiro[5.5]undecan-7-ol

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Chemical Property of (7S,11R)-2-Benzyl-11-(tert-butyl-dimethyl-silanyloxy)-2-aza-spiro[5.5]undecan-7-ol

Chemical Property:

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Technology Process of (7S,11R)-2-Benzyl-11-(tert-butyl-dimethyl-silanyloxy)-2-aza-spiro[5.5]undecan-7-ol

There total 6 articles about (7S,11R)-2-Benzyl-11-(tert-butyl-dimethyl-silanyloxy)-2-aza-spiro[5.5]undecan-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 100-39-0
benzyl bromide

: 120186-10-9
(7S,11R)-11-(tert-Butyl-dimethyl-silanyloxy)-2-aza-spiro[5.5]undecan-7-ol

: 120186-08-5
(7S,11R)-2-Benzyl-11-(tert-butyl-dimethyl-silanyloxy)-2-aza-spiro[5.5]undecan-7-ol

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 60 ℃;
DOI:10.1016/0040-4039(88)85149-9

Reference yield:

: (3R,8aR)-(-)-3-phenyl-3,7,8,8a-tetrahydro-2H-oxazolo<3,2-a>pyridine

: 120186-08-5
(7S,11R)-2-Benzyl-11-(tert-butyl-dimethyl-silanyloxy)-2-aza-spiro[5.5]undecan-7-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 45 percent

2: 60 percent / imidazole / dimethylformamide

3: 100 percent / LiAlH₄ / diethyl ether / 0.33 h / 0 °C

4: 81 percent / H₂, Pd(OH)2/C / methanol / 18 h

5: 87 percent / NaHCO₃ / dimethylformamide / 60 °C

With 1H-imidazole; palladium dihydroxide; lithium aluminium tetrahydride; hydrogen; sodium hydrogencarbonate; In methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(88)85149-9

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 120186-08-5
(7S,11R)-2-Benzyl-11-(tert-butyl-dimethyl-silanyloxy)-2-aza-spiro[5.5]undecan-7-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / imidazole / dimethylformamide

2: 100 percent / LiAlH₄ / diethyl ether / 0.33 h / 0 °C

3: 81 percent / H₂, Pd(OH)2/C / methanol / 18 h

4: 87 percent / NaHCO₃ / dimethylformamide / 60 °C

With 1H-imidazole; palladium dihydroxide; lithium aluminium tetrahydride; hydrogen; sodium hydrogencarbonate; In methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(88)85149-9