1,1-bis(N-methyl-2-phenyl-4-imidazolyl)-2-(N-methyl-2-imidazolyl)-1-hydroxyethane

Base Information

Chemical Name:1,1-bis(N-methyl-2-phenyl-4-imidazolyl)-2-(N-methyl-2-imidazolyl)-1-hydroxyethane
CAS No.:86119-44-0
Molecular Formula:C₂₆H₂₆N₆O
Molecular Weight:438.532
Hs Code.:

Synonyms:1,1-bis(N-methyl-2-phenyl-4-imidazolyl)-2-(N-methyl-2-imidazolyl)-1-hydroxyethane

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Chemical Property of 1,1-bis(N-methyl-2-phenyl-4-imidazolyl)-2-(N-methyl-2-imidazolyl)-1-hydroxyethane

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Technology Process of 1,1-bis(N-methyl-2-phenyl-4-imidazolyl)-2-(N-methyl-2-imidazolyl)-1-hydroxyethane

There total 6 articles about 1,1-bis(N-methyl-2-phenyl-4-imidazolyl)-2-(N-methyl-2-imidazolyl)-1-hydroxyethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1739-84-0
1,2-dimethyl-1H-imidazole

: 86119-43-9
bis(N-methyl-2-phenyl-4-imidazolyl) ketone

: 86119-44-0
1,1-bis(N-methyl-2-phenyl-4-imidazolyl)-2-(N-methyl-2-imidazolyl)-1-hydroxyethane

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; 1.) -78 deg C, 20 min, 2.) RT, overnight;
DOI:10.1021/ja00354a025

Reference yield:

: 670-96-2
1-phenyl-1H-pyrazole

: 86119-44-0
1,1-bis(N-methyl-2-phenyl-4-imidazolyl)-2-(N-methyl-2-imidazolyl)-1-hydroxyethane

Guidance literature:: Multi-step reaction with 6 steps

1: NaH / tetrahydrofuran

2: 70 percent / BuLi

3: 82 percent / pyridinium chlorochromate, NaOAc / CH₂Cl₂ / 19 h / Ambient temperature

4: CH₂Cl₂ / 0.5 h

5: 0.60 g / HCl conc. / aq. ethanol / 36 h / Heating

6: 19 percent / BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 20 min, 2.) RT, overnight

With hydrogenchloride; n-butyllithium; sodium acetate; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; ethanol; hexane; dichloromethane;
DOI:10.1021/ja00354a025

Reference yield:

: 86119-53-1
1-(ethoxymethyl)-2-phenyl-1H-imidazole

: 86119-44-0
1,1-bis(N-methyl-2-phenyl-4-imidazolyl)-2-(N-methyl-2-imidazolyl)-1-hydroxyethane

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / BuLi

2: 82 percent / pyridinium chlorochromate, NaOAc / CH₂Cl₂ / 19 h / Ambient temperature

3: CH₂Cl₂ / 0.5 h

4: 0.60 g / HCl conc. / aq. ethanol / 36 h / Heating

5: 19 percent / BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 20 min, 2.) RT, overnight

With hydrogenchloride; n-butyllithium; sodium acetate; pyridinium chlorochromate; In tetrahydrofuran; ethanol; hexane; dichloromethane;
DOI:10.1021/ja00354a025