6-chloro-7-phenyl-1,2,3,4-tetrahydropyrrolo-[1, 2-a]pyrazine-8-carbonitrile

Base Information

Chemical Name:6-chloro-7-phenyl-1,2,3,4-tetrahydropyrrolo-[1, 2-a]pyrazine-8-carbonitrile
CAS No.:1352087-22-9
Molecular Formula:C₁₄H₁₂ClN₃
Molecular Weight:257.722
Hs Code.:

Synonyms:6-chloro-7-phenyl-1,2,3,4-tetrahydropyrrolo-[1, 2-a]pyrazine-8-carbonitrile

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Chemical Property of 6-chloro-7-phenyl-1,2,3,4-tetrahydropyrrolo-[1, 2-a]pyrazine-8-carbonitrile

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Technology Process of 6-chloro-7-phenyl-1,2,3,4-tetrahydropyrrolo-[1, 2-a]pyrazine-8-carbonitrile

There total 6 articles about 6-chloro-7-phenyl-1,2,3,4-tetrahydropyrrolo-[1, 2-a]pyrazine-8-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1352087-21-8
tert-butyl {2-[2-chloro-4-cyano-3-phenyl-1H-pyrrol-1-yl]ethyl}carbamate

: 1352087-22-9
6-chloro-7-phenyl-1,2,3,4-tetrahydropyrrolo-[1, 2-a]pyrazine-8-carbonitrile

Guidance literature:: tert-butyl {2-[2-chloro-4-cyano-3-phenyl-1H-pyrrol-1-yl]ethyl}carbamate; With hydrogenchloride; water; In ethanol; at 90 ℃; for 1h;

formaldehyd; In ethanol; at 90 ℃; for 4h;

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: C₁₃H₁₂ClN₃*ClH

: 1352087-22-9
6-chloro-7-phenyl-1,2,3,4-tetrahydropyrrolo-[1, 2-a]pyrazine-8-carbonitrile

Guidance literature:: formaldehyd; C₁₃H₁₂ClN₃*ClH; With hydrogenchloride; In ethanol; water; for 4h; Heating;

With ammonium hydroxide; In ethanol; water;

Reference yield:

: 1885-38-7
cinnamic nitrile

: 1352087-22-9
6-chloro-7-phenyl-1,2,3,4-tetrahydropyrrolo-[1, 2-a]pyrazine-8-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / 20 - 25 °C

2.1: N-chloro-succinimide / tetrahydrofuran / 48 h / Reflux

3.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / acetonitrile

3.2: 4 h / Reflux

4.1: hydrogenchloride / ethanol; water / 1 h / 90 °C

5.1: hydrogenchloride / ethanol; water / 4 h / Heating

With hydrogenchloride; N-chloro-succinimide; potassium tert-butylate; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; ethanol; water; acetonitrile;