5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid

Base Information

Chemical Name:5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid
CAS No.:1092445-74-3
Molecular Formula:C₂₂H₂₁F₂NO₃
Molecular Weight:385.41
Hs Code.:

Synonyms:5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid

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Chemical Property of 5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid

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Technology Process of 5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid

There total 6 articles about 5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 14559-88-7
2,2-dimethylethenylboronic acid

: 1092447-91-0
5,6-difluoro-2-(2-iodo-3-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester

: 1092445-74-3
5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid

: 1092447-92-1
5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid ethyl ester

Guidance literature:: With water; potassium carbonate; palladium anchored homogeneous catalyst, FibreCatPd⁽⁰⁾ (4.84percentPd); In 1,4-dioxane; ethanol; at 120 ℃; for 6h; Microwave irradiation;

Reference yield:

: 854519-97-4
(4,5-difluoro-1,2-phenylene)dimethanol

: 1092445-74-3
5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid

: 1092447-92-1
5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen bromide / water / 3 h / 80 °C

2.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / acetonitrile / 3 h / Heating / reflux

3.1: hydrogenchloride; water / ethanol / 1 h / 20 °C

3.2: 10 °C / pH 9 - 10

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

5.1: water; potassium carbonate / palladium anchored homogeneous catalyst, FibreCatPd⁽⁰⁾ (4.84percentPd) / 1,4-dioxane; ethanol / 6 h / 120 °C / Microwave irradiation

With hydrogenchloride; water; hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium anchored homogeneous catalyst, FibreCatPd⁽⁰⁾ (4.84percentPd); In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1092447-71-6
2-amino-5,6-difluoro-indan-2-carboxylic acid ethyl ester

: 1092445-74-3
5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid

: 1092447-92-1
5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

2: water; potassium carbonate / palladium anchored homogeneous catalyst, FibreCatPd⁽⁰⁾ (4.84percentPd) / 1,4-dioxane; ethanol / 6 h / 120 °C / Microwave irradiation

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium anchored homogeneous catalyst, FibreCatPd⁽⁰⁾ (4.84percentPd); In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;