5,6-difluoro-2-(2-isobutyl-3-methyl-benzoylamino)-indan-2-carboxylic acid

Base Information

Chemical Name:5,6-difluoro-2-(2-isobutyl-3-methyl-benzoylamino)-indan-2-carboxylic acid
CAS No.:1092445-75-4
Molecular Formula:C₂₂H₂₃F₂NO₃
Molecular Weight:387.426
Hs Code.:

Synonyms:5,6-difluoro-2-(2-isobutyl-3-methyl-benzoylamino)-indan-2-carboxylic acid

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Chemical Property of 5,6-difluoro-2-(2-isobutyl-3-methyl-benzoylamino)-indan-2-carboxylic acid

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Technology Process of 5,6-difluoro-2-(2-isobutyl-3-methyl-benzoylamino)-indan-2-carboxylic acid

There total 7 articles about 5,6-difluoro-2-(2-isobutyl-3-methyl-benzoylamino)-indan-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1092445-74-3
5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid

: 1092445-75-4
5,6-difluoro-2-(2-isobutyl-3-methyl-benzoylamino)-indan-2-carboxylic acid

Guidance literature:: With hydrogen; acetic acid; 5%-palladium/activated carbon; In ethanol; at 20 - 95 ℃; under 2585.81 Torr; Heating / reflux;

Reference yield:

: 1092447-71-6
2-amino-5,6-difluoro-indan-2-carboxylic acid ethyl ester

: 1092445-75-4
5,6-difluoro-2-(2-isobutyl-3-methyl-benzoylamino)-indan-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

2: water; potassium carbonate / palladium anchored homogeneous catalyst, FibreCatPd⁽⁰⁾ (4.84percentPd) / 1,4-dioxane; ethanol / 6 h / 120 °C / Microwave irradiation

3: hydrogen; acetic acid / 5%-palladium/activated carbon / ethanol / 20 - 95 °C / 2585.81 Torr / Heating / reflux

With water; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; 5%-palladium/activated carbon; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 915944-27-3
1,2-bis(bromomethyl)-4,5-difluorobenzene

: 1092445-75-4
5,6-difluoro-2-(2-isobutyl-3-methyl-benzoylamino)-indan-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / acetonitrile / 3 h / Heating / reflux

2.1: hydrogenchloride; water / ethanol / 1 h / 20 °C

2.2: 10 °C / pH 9 - 10

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4.1: water; potassium carbonate / palladium anchored homogeneous catalyst, FibreCatPd⁽⁰⁾ (4.84percentPd) / 1,4-dioxane; ethanol / 6 h / 120 °C / Microwave irradiation

5.1: hydrogen; acetic acid / 5%-palladium/activated carbon / ethanol / 20 - 95 °C / 2585.81 Torr / Heating / reflux

With hydrogenchloride; water; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; 5%-palladium/activated carbon; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetonitrile;