943239-53-0Relevant academic research and scientific papers
TAXANE AND ABEO-TAXANE ANALOGS
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, (2013/07/25)
The present application discloses new taxane analogs, intermediates and methods for producing them. The present application is also directed to pharmaceutical formulations comprising abeo-taxanes and methods of treating cancer with the abeo-taxanes.
TAXANE ANALOGUES, THEIR USE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION
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, (2011/04/14)
The present invention relates to novel taxane analogues, processes of making the novel taxane analogues, compositions containing the novel taxane analogues, and their use in treating cancer and neurodegenerative disorders. In some embodiments, the taxane analogues are represented by the generic structure of formula (I) : wherein R1, R2,R3 and A are defined herein; and esters especially pro-drugs thereof wherein one or more of the hydroxy! groups is esterified to form an in-vivo hydrolysable ester group; or pharmaceutically acceptable salts thereof.
TAXANE ANALOGS FOR THE TREATMENT OF BRAIN CANCER
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, (2008/12/07)
Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a s
BIOLOGICALLY ACTIVE TAXANE ANALOGS AND METHODS OF TREATMENT BY ORAL ADMINISTRATION
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, (2008/12/04)
The present invention relates to a novel chemical compound of formula S-(I) for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.
PROCESSES FOR TAXANE DERIVATIVES AND INTERMEDIATES USEFUL THEREIN
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Page/Page column 33, (2008/06/13)
The application provides a process for the preparation of taxane derivatives and intermediates useful in such processes.
