92950-45-3

Usage

Source

Derived from the Pacific yew tree (Taxus brevifolia)

Use

Commonly used in the synthesis of the anti-cancer drug paclitaxel (Taxol)

Chemical structure

Unique structure with multiple functional groups

Functional groups

Contains dehydro and deacetyl groups

Stereochemistry

Features an epimeric carbon at the C7 position

Biological activity

Exhibits significant biological activity

Intermediate

Serves as a valuable intermediate in the production of paclitaxel

Chemotherapy agent

Paclitaxel, synthesized from 10-dehydro 10-deacetyl 7-epibaccatin V, is a widely used chemotherapy agent

Cancer treatment

Paclitaxel is used for the treatment of various cancers, including ovarian, breast, and lung cancer

Importance

The intricate structure and biological activity of 10-dehydro 10-deacetyl 7-epibaccatin V make it a crucial component in the development of life-saving cancer treatments.

Upstream product

• 32981-86-5 10-deacetylbaccatin III 

Downstream Products

• 651293-82-2 7,13-bis(triethylsilyl)-10-dehydro-10-deacetylbaccatin III 
• 943239-53-0 C₄₁H₆₆O₁₀Si₂ 
• 1447950-53-9 C₄₈H₆₇NO₁₅ 
• 1269040-35-8 C₄₃H₆₁NO₁₅ 
• 1029600-32-5 SY₅₈₆-170.1 
• 1067643-34-8 C₃₄H₄₂O₁₁ 
• 1269040-80-3 SY₆₃₄-70AP₁ 
• 1269040-79-0 C₄₅H₆₁NO₁₆ 
• 1269040-78-9 SY₆₃₄-69P₁ 
• 1269040-76-7 SY₆₃₄-58P₂ 
• 1269040-73-4 SY₆₃₄-58P₁ 
• 1269040-70-1 SY₆₃₄-55P₁c 
• 1269040-71-2 SY₆₃₄-55P₂c 
• 1051405-47-0 C₄₆H₆₃NO₁₅ 

Relevant academic research and scientific papers

TAXANE AND ABEO-TAXANE ANALOGS

The present application discloses new taxane analogs, intermediates and methods for producing them. The present application is also directed to pharmaceutical formulations comprising abeo-taxanes and methods of treating cancer with the abeo-taxanes.

TAXANE ANALOGUES, THEIR USE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION

The present invention relates to novel taxane analogues, processes of making the novel taxane analogues, compositions containing the novel taxane analogues, and their use in treating cancer and neurodegenerative disorders. In some embodiments, the taxane analogues are represented by the generic structure of formula (I) : wherein R1, R2,R3 and A are defined herein; and esters especially pro-drugs thereof wherein one or more of the hydroxy! groups is esterified to form an in-vivo hydrolysable ester group; or pharmaceutically acceptable salts thereof.

TAXANE ANALOGS FOR THE TREATMENT OF BRAIN CANCER

Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a s

BIOLOGICALLY ACTIVE TAXANE ANALOGS AND METHODS OF TREATMENT BY ORAL ADMINISTRATION

The present invention relates to a novel chemical compound of formula S-(I) for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.

PROCESSES FOR TAXANE DERIVATIVES AND INTERMEDIATES USEFUL THEREIN

The application provides a process for the preparation of taxane derivatives and intermediates useful in such processes.

Synthesis of modified baccatins via an oxidation-reduction protocol

(12R)-7-trietylsilyl-11-dihydro-10-deacetylbaccatin III (2), -deacetylbaccatin III (4) and the 7,8-seco baccatin III (5a) were synthesized from 10-deacetylbaccatin III via an oxidation-reduction protocol.

THE CHEMISTRY AND OCCURRENCE OF TAXANE DERIVATIVES. XIII. THE OXIDATION OF 10-DEACETYLBACCATIN III

The three secondary hydroxyls of 10-deacetylbaccatin III, 1, can be selectively oxidized.However, only the 13-dehydro derivative is stable under the reaction conditions, whereas the 10- and the 7-dehydro derivatives undergo epimerization at C-7 and oxetan