(2S,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-hydroxy-2-methyl-hexanoic acid methoxy-methyl-amide

Base Information

Chemical Name:(2S,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-hydroxy-2-methyl-hexanoic acid methoxy-methyl-amide
CAS No.:130258-64-9
Molecular Formula:C₂₅H₃₇NO₄Si
Molecular Weight:443.659
Hs Code.:

Synonyms:(2S,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-hydroxy-2-methyl-hexanoic acid methoxy-methyl-amide

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Chemical Property of (2S,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-hydroxy-2-methyl-hexanoic acid methoxy-methyl-amide

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Technology Process of (2S,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-hydroxy-2-methyl-hexanoic acid methoxy-methyl-amide

There total 6 articles about (2S,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-hydroxy-2-methyl-hexanoic acid methoxy-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 130258-63-8
(3S,5R)-5-[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-methyl-dihydro-furan-2-one

: 130258-64-9
(2S,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-hydroxy-2-methyl-hexanoic acid methoxy-methyl-amide

Guidance literature:: With trimethylaluminum; In benzene; Ambient temperature;
DOI:10.1248/cpb.38.1778

Reference yield:

: 125022-97-1
Acetic acid (E)-(R)-1-((S)-1-methoxymethoxy-ethyl)-4-oxo-but-2-enyl ester

: 130258-64-9
(2S,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-hydroxy-2-methyl-hexanoic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / 10percent Pd-C / ethanol

2: HOH / methanol; H₂O

3: pyridinium chlorochromate

5: 1.) lithium diisopropylamide / 1.) THF, -70 deg C, 2.) -90 deg C, 2.5 h

6: 90 percent / Me₃Al / benzene / Ambient temperature

With water; hydrogen; trimethylaluminum; pyridinium chlorochromate; lithium diisopropyl amide; palladium on activated charcoal; In methanol; ethanol; water; benzene;
DOI:10.1248/cpb.38.1778

Reference yield:

: (R)-5-((S)-1-Methoxymethoxy-ethyl)-tetrahydro-furan-2-ol

: 130258-64-9
(2S,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-hydroxy-2-methyl-hexanoic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridinium chlorochromate

3: 1.) lithium diisopropylamide / 1.) THF, -70 deg C, 2.) -90 deg C, 2.5 h

4: 90 percent / Me₃Al / benzene / Ambient temperature

With trimethylaluminum; pyridinium chlorochromate; lithium diisopropyl amide; In benzene;
DOI:10.1248/cpb.38.1778