(3S,4R,5S)-4-(methylaminomethyl)-2-benzyl-3-ethoxycarbonyl-3,5-dimethylisoxazolidine

Base Information

Chemical Name:(3S,4R,5S)-4-(methylaminomethyl)-2-benzyl-3-ethoxycarbonyl-3,5-dimethylisoxazolidine
CAS No.:1373354-26-7
Molecular Formula:C₁₇H₂₆N₂O₃
Molecular Weight:306.405
Hs Code.:

Synonyms:(3S,4R,5S)-4-(methylaminomethyl)-2-benzyl-3-ethoxycarbonyl-3,5-dimethylisoxazolidine

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Chemical Property of (3S,4R,5S)-4-(methylaminomethyl)-2-benzyl-3-ethoxycarbonyl-3,5-dimethylisoxazolidine

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Technology Process of (3S,4R,5S)-4-(methylaminomethyl)-2-benzyl-3-ethoxycarbonyl-3,5-dimethylisoxazolidine

There total 3 articles about (3S,4R,5S)-4-(methylaminomethyl)-2-benzyl-3-ethoxycarbonyl-3,5-dimethylisoxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1373354-25-6
(3R,4S,5R)-ethyl 2-benzyl-4-formyl-3,5-dimethylisoxazolidine-3-carboxylate

: 74-89-5
methylamine

: 1373354-26-7
(3S,4R,5S)-4-(methylaminomethyl)-2-benzyl-3-ethoxycarbonyl-3,5-dimethylisoxazolidine

Guidance literature:: (3R,4S,5R)-ethyl 2-benzyl-4-formyl-3,5-dimethylisoxazolidine-3-carboxylate; methylamine; With sodium cyanoborohydride; acetic acid; In methanol; ethanol; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In methanol; ethanol; water;
DOI:10.1016/j.tetasy.2012.02.003

Reference yield:

: 617-35-6
2-oxo-propionic acid ethyl ester

: 1373354-26-7
(3S,4R,5S)-4-(methylaminomethyl)-2-benzyl-3-ethoxycarbonyl-3,5-dimethylisoxazolidine

Guidance literature:: Multi-step reaction with 3 steps

2: (5R)-(+)-2,2,3-trimethyl-5-benzyl-4-imidazolidinone monohydrochloride; water / nitromethane / 22 h / 20 °C

3: sodium cyanoborohydride; acetic acid / methanol; ethanol / 2 h / 20 °C

With (5R)-(+)-2,2,3-trimethyl-5-benzyl-4-imidazolidinone monohydrochloride; water; sodium cyanoborohydride; acetic acid; In methanol; nitromethane; ethanol;
DOI:10.1016/j.tetasy.2012.02.003

Reference yield:

: 29601-98-7
N-benzylhydroxylamine hydrochloride

: 1373354-26-7
(3S,4R,5S)-4-(methylaminomethyl)-2-benzyl-3-ethoxycarbonyl-3,5-dimethylisoxazolidine

Guidance literature:: Multi-step reaction with 3 steps

2: (5R)-(+)-2,2,3-trimethyl-5-benzyl-4-imidazolidinone monohydrochloride; water / nitromethane / 22 h / 20 °C

3: sodium cyanoborohydride; acetic acid / methanol; ethanol / 2 h / 20 °C

With (5R)-(+)-2,2,3-trimethyl-5-benzyl-4-imidazolidinone monohydrochloride; water; sodium cyanoborohydride; acetic acid; In methanol; nitromethane; ethanol;
DOI:10.1016/j.tetasy.2012.02.003