4-{[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]carbonyl}cyclohexanone

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Chemical Name:4-{[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]carbonyl}cyclohexanone
CAS No.:1412493-65-2
Molecular Formula:C₂₂H₁₉F₃N₄O₂S
Molecular Weight:460.48
Hs Code.:

Synonyms:4-{[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]carbonyl}cyclohexanone

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Chemical Property of 4-{[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]carbonyl}cyclohexanone

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Technology Process of 4-{[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]carbonyl}cyclohexanone

There total 5 articles about 4-{[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]carbonyl}cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312535-01-5
N-[3-methyl-5-(1,3-thiazol-5-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine

: N-Methoxy-N-methyl-1,4-dioxaspiro<4.5>decane-8-carboxamide

: 1412493-65-2
4-{[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]carbonyl}cyclohexanone

: 1412491-24-7
C₂₄H₂₃F₃N₄O₃S

Guidance literature:: N-[3-methyl-5-(1,3-thiazol-5-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; for 0.5h;

N-Methoxy-N-methyl-1,4-dioxaspiro<4.5>decane-8-carboxamide; In tetrahydrofuran; at -78 - 20 ℃; for 16h;

Reference yield:

: 33034-67-2
2-chloro-4-trifluoromethylpyrimidine

: 1412493-65-2
4-{[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]carbonyl}cyclohexanone

: 1412491-24-7
C₂₄H₂₃F₃N₄O₃S

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanesulfonic acid / 1,4-dioxane / Reflux

1.2: pH 7 - 8

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / Reflux

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / Reflux

4.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0.5 h

4.2: 16 h / -78 - 20 °C

With methanesulfonic acid; potassium acetate; sodium carbonate; lithium diisopropyl amide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; n-heptane; ethylbenzene; water;

Reference yield:

: 1312535-00-4
N-[3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine

: 1412493-65-2
4-{[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]carbonyl}cyclohexanone

: 1412491-24-7
C₂₄H₂₃F₃N₄O₃S

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / Reflux

2.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0.5 h

2.2: 16 h / -78 - 20 °C

With sodium carbonate; lithium diisopropyl amide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; n-heptane; ethylbenzene; water;