1312535-00-4

Basic information

• Product Name: N-[3-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-4-(trifluoroMethyl)pyriMidin-2-aMine
• Synonyms: N-[3-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-4-(trifluoroMethyl)pyriMidin-2-aMine
• CAS NO: 1312535-00-4
• Molecular Weight: 379.19
• EINECS: -0
• Mol File: 1312535-00-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-[3-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-4-(trifluoroMethyl)pyriMidin-2-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-4-(trifluoroMethyl)pyriMidin-2-aMine(1312535-00-4)
• EPA Substance Registry System: N-[3-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-4-(trifluoroMethyl)pyriMidin-2-aMine(1312535-00-4)

Safety Data

• Hazardous Substances Data: 1312535-00-4(Hazardous Substances Data)

Upstream product

• 74586-53-1 3-bromo-5-methylaniline 
• 33034-67-2 2-chloro-4-trifluoromethylpyrimidine 
• 1312534-99-8 N-(3-bromo-5-methylphenyl)-4-(trifluoromethyl)pyrimidin-2-amine 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1412492-90-0 N-(3-{2-[(2,2-dimethyl-4-oxocyclohexyl)carbonyl]-1,3-thiazol-5-yl}-5-methylphenyl)-4-(trifluoromethyl)pyrimidin-2-aminium trifluoroacetate 
• 1312535-01-5 N-[3-methyl-5-(1,3-thiazol-5-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine 
• 1412491-02-1 trans-4-{(1R)-1-hydroxy-1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]ethyl}cyclohexanecarboxylic acid 
• 1412491-03-2 trans-4-{(1S)-1-hydroxy-1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]ethyl}cyclohexanecarboxylic acid 
• 1412493-65-2 4-{[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]carbonyl}cyclohexanone 
• 1412491-24-7 C₂₄H₂₃F₃N₄O₃S 
• 1426335-54-7 methyl 4-{hydroxyl[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]methyl}cyclohexanecarboxylate 
• 1412492-88-6 trans-4-{(1R)-2-fluoro-1-hydroxy-1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]ethyl}cyclohexanecarboxylic acid 
• 1412492-87-5 trans-4-{(1S)-2-fluoro-1-hydroxy-1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]ethyl}cyclohexanecarboxylic acid 
• 1412493-05-0 1,4-dioxaspiro[4.5]dec-8-yl[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]methanol 
• 1412493-06-1 4-{1-hydroxy-1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]ethyl}-1-methylcyclohexanol 

Relevant articles and documents

SUBSTITUTED PHENYL SPLEEN TYROSINE KINASE (Syk) INHIBITORS

The invention provides certain substituted phenyl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).

SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS

The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy,Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.

AMINOPYRIMIDINES AS SYK INHIBITORS

The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.