2-(4-methanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol

Base Information

Chemical Name:2-(4-methanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol
CAS No.:648906-10-9
Molecular Formula:C₂₈H₂₉NO₅S₂
Molecular Weight:523.674
Hs Code.:

Synonyms:2-(4-methanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol

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Chemical Property of 2-(4-methanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol

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Technology Process of 2-(4-methanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol

There total 19 articles about 2-(4-methanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 943439-50-7
4'-Bromo-4'-desmethoxyarzoxifene

: 20277-69-4
sodium methansulfinate

: 648906-10-9
2-(4-methanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol

Guidance literature:: With sodium hydroxide; copper(l) iodide; L-proline; In dimethyl sulfoxide; at 110 ℃; for 13h;
DOI:10.1021/jm070079j

Reference yield: 68.0%

: 648906-09-6
1-(2-{4-[6-benzyloxy-2-(4-methanesulfonyl-phenyl)-benzo[b]thiophen-3-yloxy]-phenoxy}-ethyl)-piperidine trifluoroacetate

: 648906-10-9
2-(4-methanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol

Guidance literature:: With ammonium formate; palladium dihydroxide; In methanol; ethyl acetate; for 1h; Heating / reflux;

Reference yield:

: 943439-52-9
2-(4-bromo-phenyl)-6-methoxy-benzo[b]thiophene

: 648906-10-9
2-(4-methanesulfonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / N-bromoacetamide / CH₂Cl₂ / 2 h / 20 °C

2.1: 65 percent / TFA; aq. H₂O₂ / CH₂Cl₂ / 2 h / 20 °C

3.1: NaH / dimethylformamide / 0.33 h

3.2: 94 percent / dimethylformamide / 1 h / 20 °C

4.1: HCl / CH₂Cl₂; diethyl ether / 1 h

4.2: 85 percent / TMSCl; Ph₃P / tetrahydrofuran / 8 h / Heating

5.1: HCl / CH₂Cl₂; diethyl ether / 0.5 h / 20 °C

5.2: 82 percent / BF₃*SMe₂ / CH₂Cl₂ / 5 h / 20 °C

6.1: 90 percent / NaOH / CuI; L-proline / dimethylsulfoxide / 13 h / 110 °C

With hydrogenchloride; sodium hydroxide; dihydrogen peroxide; sodium hydride; trifluoroacetic acid; N-bromoacetamide; copper(l) iodide; L-proline; In diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm070079j