4'-Bromo-4'-desmethoxyarzoxifene

Base Information

Chemical Name:4'-Bromo-4'-desmethoxyarzoxifene
CAS No.:943439-50-7
Molecular Formula:C₂₇H₂₆BrNO₃S
Molecular Weight:524.478
Hs Code.:

Synonyms:4'-Bromo-4'-desmethoxyarzoxifene

Suppliers and Price of 4'-Bromo-4'-desmethoxyarzoxifene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4'-Bromo-4'-desmethoxyarzoxifene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4'-Bromo-4'-desmethoxyarzoxifene

There total 7 articles about 4'-Bromo-4'-desmethoxyarzoxifene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 943439-56-3
6-methoxy-3-{4-[2-(1-piperidinyl)ethoxy]phenoxy}-2-(4-bromophenyl)benzo[b]thiophene

: 943439-50-7
4'-Bromo-4'-desmethoxyarzoxifene

Guidance literature:: 6-methoxy-3-{4-[2-(1-piperidinyl)ethoxy]phenoxy}-2-(4-bromophenyl)benzo[b]thiophene; With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃; for 0.5h;

With boron dimethyl-trifluoro sulphide; In dichloromethane; at 20 ℃; for 5h; Further stages.;
DOI:10.1021/jm070079j

Reference yield:

: 943439-53-0
6-methoxy-2-(4-bromophenyl)-3-bromobenzo[b]thiophene

: 943439-50-7
4'-Bromo-4'-desmethoxyarzoxifene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 65 percent / TFA; aq. H₂O₂ / CH₂Cl₂ / 2 h / 20 °C

2.1: NaH / dimethylformamide / 0.33 h

2.2: 94 percent / dimethylformamide / 1 h / 20 °C

3.1: HCl / CH₂Cl₂; diethyl ether / 1 h

3.2: 85 percent / TMSCl; Ph₃P / tetrahydrofuran / 8 h / Heating

4.1: HCl / CH₂Cl₂; diethyl ether / 0.5 h / 20 °C

4.2: 82 percent / BF₃*SMe₂ / CH₂Cl₂ / 5 h / 20 °C

With hydrogenchloride; dihydrogen peroxide; sodium hydride; trifluoroacetic acid; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm070079j

Reference yield:

: 943439-54-1
3-bromo-2-(4-bromophenyl)-6-methoxy-1-oxidobenzothiophen-1-ium

: 943439-50-7
4'-Bromo-4'-desmethoxyarzoxifene

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.33 h

1.2: 94 percent / dimethylformamide / 1 h / 20 °C

2.1: HCl / CH₂Cl₂; diethyl ether / 1 h

2.2: 85 percent / TMSCl; Ph₃P / tetrahydrofuran / 8 h / Heating

3.1: HCl / CH₂Cl₂; diethyl ether / 0.5 h / 20 °C

3.2: 82 percent / BF₃*SMe₂ / CH₂Cl₂ / 5 h / 20 °C

With hydrogenchloride; sodium hydride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm070079j