6-methoxy-3-{4-[2-(1-piperidinyl)ethoxy]phenoxy}-2-(4-bromophenyl)benzo[b]thiophene

Base Information

Chemical Name:6-methoxy-3-{4-[2-(1-piperidinyl)ethoxy]phenoxy}-2-(4-bromophenyl)benzo[b]thiophene
CAS No.:943439-56-3
Molecular Formula:C₂₈H₂₈BrNO₃S
Molecular Weight:538.505
Hs Code.:

Synonyms:6-methoxy-3-{4-[2-(1-piperidinyl)ethoxy]phenoxy}-2-(4-bromophenyl)benzo[b]thiophene

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Chemical Property of 6-methoxy-3-{4-[2-(1-piperidinyl)ethoxy]phenoxy}-2-(4-bromophenyl)benzo[b]thiophene

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Technology Process of 6-methoxy-3-{4-[2-(1-piperidinyl)ethoxy]phenoxy}-2-(4-bromophenyl)benzo[b]thiophene

There total 6 articles about 6-methoxy-3-{4-[2-(1-piperidinyl)ethoxy]phenoxy}-2-(4-bromophenyl)benzo[b]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 943439-55-2
6-methoxy-3-{4-[2-(1-piperidinyl)ethoxy]phenoxy}-2-(4-bromophenyl)benzo[b]thiophene S-oxide

: 943439-56-3
6-methoxy-3-{4-[2-(1-piperidinyl)ethoxy]phenoxy}-2-(4-bromophenyl)benzo[b]thiophene

Guidance literature:: 6-methoxy-3-{4-[2-(1-piperidinyl)ethoxy]phenoxy}-2-(4-bromophenyl)benzo[b]thiophene S-oxide; With hydrogenchloride; In diethyl ether; dichloromethane; for 1h;

With chloro-trimethyl-silane; triphenylphosphine; In tetrahydrofuran; for 8h; Further stages.; Heating;
DOI:10.1021/jm070079j

Reference yield:

: 943439-53-0
6-methoxy-2-(4-bromophenyl)-3-bromobenzo[b]thiophene

: 943439-56-3
6-methoxy-3-{4-[2-(1-piperidinyl)ethoxy]phenoxy}-2-(4-bromophenyl)benzo[b]thiophene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 65 percent / TFA; aq. H₂O₂ / CH₂Cl₂ / 2 h / 20 °C

2.1: NaH / dimethylformamide / 0.33 h

2.2: 94 percent / dimethylformamide / 1 h / 20 °C

3.1: HCl / CH₂Cl₂; diethyl ether / 1 h

3.2: 85 percent / TMSCl; Ph₃P / tetrahydrofuran / 8 h / Heating

With hydrogenchloride; dihydrogen peroxide; sodium hydride; trifluoroacetic acid; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm070079j

Reference yield:

: 943439-54-1
3-bromo-2-(4-bromophenyl)-6-methoxy-1-oxidobenzothiophen-1-ium

: 943439-56-3
6-methoxy-3-{4-[2-(1-piperidinyl)ethoxy]phenoxy}-2-(4-bromophenyl)benzo[b]thiophene

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.33 h

1.2: 94 percent / dimethylformamide / 1 h / 20 °C

2.1: HCl / CH₂Cl₂; diethyl ether / 1 h

2.2: 85 percent / TMSCl; Ph₃P / tetrahydrofuran / 8 h / Heating

With hydrogenchloride; sodium hydride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm070079j