(4-oxo-4-phenylbutylidene)bisphosphonic acid tetraethyl ester

Base Information

• Chemical Name: (4-oxo-4-phenylbutylidene)bisphosphonic acid tetraethyl ester
• CAS No.: 136496-85-0
• Molecular Formula: C₁₈H₃₀O₇P₂
• Molecular Weight: 420.38
• Mol file: 136496-85-0.mol

Synonyms:(4-oxo-4-phenylbutylidene)bisphosphonic acid tetraethyl ester

Chemical Property of (4-oxo-4-phenylbutylidene)bisphosphonic acid tetraethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (4-oxo-4-phenylbutylidene)bisphosphonic acid tetraethyl ester

There total 2 articles about (4-oxo-4-phenylbutylidene)bisphosphonic acid tetraethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-bis(diethylphosphono)ethylene (37465-31-9) + acetophenone (98-86-2) → (4-oxo-4-phenylbutylidene)bisphosphonic acid tetraethyl ester (136496-85-0)

Guidance literature:

With potassium hydroxide; Yield given. Multistep reaction; 1.) THF 2.) 20 deg C, 60 min;

DOI:10.1055/s-1991-26539

Reference yield:

→ (4-oxo-4-phenylbutylidene)bisphosphonic acid tetraethyl ester (136496-85-0)

Guidance literature:

Reference yield: 82.0%

(4-oxo-4-phenylbutylidene)bisphosphonic acid tetraethyl ester (136496-85-0) → [4-Hydroxy4-phenylbutylidene]bisphosphonic acid tetraethyl ester

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 1h;

DOI:10.1016/S0960-894X(98)00167-X

upstream raw materials:

1,1-bis(diethylphosphono)ethylene

acetophenone

Downstream raw materials:

[1-methyl-4-oxo-4-phenylbutylidene]bisphosphonic acid tetraethyl ester

[1,3,3-Trichloro-4-oxo4-phenylbutylidene]bisphosphonic acid tetraethyl ester