Ethyl 3-[2-(methoxymethoxy)phenyl]prop-2-ynoate

Base Information

Chemical Name:Ethyl 3-[2-(methoxymethoxy)phenyl]prop-2-ynoate
CAS No.:939794-48-6
Molecular Formula:C₁₃H₁₄O₄
Molecular Weight:234.252
Hs Code.:
DSSTox Substance ID:DTXSID60705004
Wikidata:Q82637635

Synonyms:939794-48-6;SCHEMBL2289043;DTXSID60705004;ethyl 3-[2-(methoxymethoxy)phenyl]prop-2-ynoate

Suppliers and Price of Ethyl 3-[2-(methoxymethoxy)phenyl]prop-2-ynoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Ethyl 3-[2-(methoxymethoxy)phenyl]prop-2-ynoate

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:234.08920892
Heavy Atom Count:17
Complexity:299

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C#CC1=CC=CC=C1OCOC

Technology Process of Ethyl 3-[2-(methoxymethoxy)phenyl]prop-2-ynoate

There total 2 articles about Ethyl 3-[2-(methoxymethoxy)phenyl]prop-2-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 541-41-3
chloroformic acid ethyl ester

: 634153-24-5
1-ethynyl-2-(methoxymethoxy)benzene

: 939794-48-6
ethyl 3-(2-methoxymethoxy)phenylpropiolate

Guidance literature:: 1-ethynyl-2-(methoxymethoxy)benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -35 ℃; for 0.333333h;

chloroformic acid ethyl ester; In tetrahydrofuran; hexane; for 0.5h;

Reference yield:

: 5533-04-0
2-(methoxymethoxy)benzaldehyde

: 939794-48-6
ethyl 3-(2-methoxymethoxy)phenylpropiolate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine / dichloromethane / 0.25 h / 0 °C

1.2: 5 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C

2.2: 3 h / -78 - 20 °C

With n-butyllithium; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/c9nj06438a

Reference yield: 100.0%

: 939794-48-6
ethyl 3-(2-methoxymethoxy)phenylpropiolate

: 939794-49-7
3-[2-(methoxymethoxy)phenyl]propiolic acid

Guidance literature:: ethyl 3-(2-methoxymethoxy)phenylpropiolate; With sodium hydroxide; water; In ethanol; at 20 ℃; for 2h;

With hydrogenchloride; In ethanol; water; pH=2;