4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyridazine

Base Information

Chemical Name:4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyridazine
CAS No.:1313705-28-0
Molecular Formula:C₁₆H₁₆F₂N₄OS
Molecular Weight:350.392
Hs Code.:

Synonyms:4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyridazine

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Chemical Property of 4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyridazine

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Technology Process of 4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyridazine

There total 7 articles about 4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313705-27-9
1,2-diethyl 4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-1,2-pyridazinedicarboxylate

: 1313705-28-0
4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyridazine

Guidance literature:: 1,2-diethyl 4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-1,2-pyridazinedicarboxylate; With water; potassium hydroxide; In ethanol; for 20h; Reflux;

With hydrogenchloride; In ethanol; water; at 70 ℃; for 0.166667h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 207226-37-7,791521-82-9
1,3-difluoro-2-vinyl-benzene

: 1313705-28-0
4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyridazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydrogencarbonate / water; chlorobenzene / 1 h / 10 - 15 °C

2.1: tetrahydrofuran; toluene / -10 - -5 °C

3.1: bromine / dichloromethane / 5 - 33 °C

4.1: methanol / 1 h / 45 - 50 °C

5.1: water; potassium hydroxide / ethanol / 20 h / Reflux

5.2: 0.17 h / 70 °C

With water; bromine; potassium hydrogencarbonate; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; chlorobenzene; toluene;

Reference yield:

: 1173693-35-0
5-(2,6-difluorophenyl)-4,5-dihydro-N,N-dimethyl-3-isoxazolecarboxamide

: 1313705-28-0
4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyridazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran; toluene / -10 - -5 °C

2.1: bromine / dichloromethane / 5 - 33 °C

3.1: methanol / 1 h / 45 - 50 °C

4.1: water; potassium hydroxide / ethanol / 20 h / Reflux

4.2: 0.17 h / 70 °C

With water; bromine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;