1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-1(2H)-pyridazinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

Base Information

Chemical Name:1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-1(2H)-pyridazinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone
CAS No.:1313705-18-8
Molecular Formula:C₂₃H₂₁F₅N₆O₂S
Molecular Weight:540.517
Hs Code.:

1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-1(2H)-pyridazinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

Synonyms:1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-1(2H)-pyridazinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

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Chemical Property of 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-1(2H)-pyridazinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

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Technology Process of 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-1(2H)-pyridazinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

There total 8 articles about 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-1(2H)-pyridazinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 345637-71-0
(5-methyl-3-trifluoromethylpyrazol-1-yl)acetic acid

: 1313705-28-0
4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyridazine

: 1313705-18-8
1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-1(2H)-pyridazinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 48h;

Reference yield:

: 207226-37-7,791521-82-9
1,3-difluoro-2-vinyl-benzene

: 1313705-18-8
1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-1(2H)-pyridazinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydrogencarbonate / water; chlorobenzene / 1 h / 10 - 15 °C

2.1: tetrahydrofuran; toluene / -10 - -5 °C

3.1: bromine / dichloromethane / 5 - 33 °C

4.1: methanol / 1 h / 45 - 50 °C

5.1: water; potassium hydroxide / ethanol / 20 h / Reflux

5.2: 0.17 h / 70 °C

6.1: dicyclohexyl-carbodiimide / dichloromethane / 48 h / 20 °C

With water; bromine; potassium hydrogencarbonate; dicyclohexyl-carbodiimide; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; chlorobenzene; toluene;

Reference yield:

: 1173693-35-0
5-(2,6-difluorophenyl)-4,5-dihydro-N,N-dimethyl-3-isoxazolecarboxamide

: 1313705-18-8
1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-1(2H)-pyridazinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran; toluene / -10 - -5 °C

2.1: bromine / dichloromethane / 5 - 33 °C

3.1: methanol / 1 h / 45 - 50 °C

4.1: water; potassium hydroxide / ethanol / 20 h / Reflux

4.2: 0.17 h / 70 °C

5.1: dicyclohexyl-carbodiimide / dichloromethane / 48 h / 20 °C

With water; bromine; dicyclohexyl-carbodiimide; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;