2,2-dimethyl-propionic acid 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester

Base Information

Chemical Name:2,2-dimethyl-propionic acid 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester
CAS No.:1229022-38-1
Molecular Formula:C₂₄H₃₄N₂O₄
Molecular Weight:414.545
Hs Code.:

Synonyms:2,2-dimethyl-propionic acid 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester

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Chemical Property of 2,2-dimethyl-propionic acid 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester

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Technology Process of 2,2-dimethyl-propionic acid 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester

There total 9 articles about 2,2-dimethyl-propionic acid 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1229022-24-5
4-hydroxy-8-methoxy-1-methyl-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-2-one

: 3282-30-2
pivaloyl chloride

: 1229022-38-1
2,2-dimethyl-propionic acid 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃;

Reference yield:

: 1145784-38-8
4-hydroxy-8-methoxy-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-2-one

: 1229022-38-1
2,2-dimethyl-propionic acid 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 1 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: hydrogen / 5%-palladium/activated carbon / water; methanol / 22 h / 36 °C / 3000.3 Torr

4.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

With hydrogen; potassium carbonate; triethylamine; lithium hexamethyldisilazane; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; water; acetone;

Reference yield:

: 102170-24-1
1-methoxypiperidin-4-one

: 1229022-38-1
2,2-dimethyl-propionic acid 8-methoxy-1-methyl-2-oxo-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: water / 0 - 20 °C

2.1: triethylamine / dmap / tetrahydrofuran / 4.5 h / 0 - 20 °C

3.1: sulfuric acid / 2.25 h / 15 - 20 °C

3.2: pH 5 - 5.5 / Cooling with ice

4.1: sodium methylate / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

4.2: pH 5 - 6 / Cooling with ice

5.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

With sulfuric acid; sodium methylate; triethylamine; dmap; In tetrahydrofuran; water; N,N-dimethyl-formamide;