(R)-3-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylpropionaldehyde

Base Information

• Chemical Name: (R)-3-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylpropionaldehyde
• CAS No.: 943764-73-6
• Molecular Formula: C₂₁H₂₄O₃
• Molecular Weight: 324.42
• Mol file: 943764-73-6.mol

Synonyms:(R)-3-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylpropionaldehyde

Chemical Property of (R)-3-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylpropionaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylpropionaldehyde

There total 1 articles about (R)-3-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylpropionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-phenylpropenal (14371-10-9) + 3-cyclopentyloxy-4-methoxyphenylboronic acid (159613-21-5) → (R)-3-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylpropionaldehyde (943764-73-6) + (S)-3-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylpropionaldehyde

Guidance literature:

With tetrafluoroboric acid; [Pd((S,S)-chiraphos)(PhCN)2](SbF₆)2; In water; acetone; at 10 ℃; for 20h; Title compound not separated from byproducts.;

DOI:10.1016/j.tetlet.2007.04.038

Reference yield: 97.0%

methanol (67-56-1) + (R)-3-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylpropionaldehyde (943764-73-6) → C22H26O4 (943764-74-7)

Guidance literature:

With potassium hydroxide; iodine; at 0 - 20 ℃; for 20h;

DOI:10.1016/j.tetlet.2007.04.038

Reference yield:

(R)-3-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylpropionaldehyde (943764-73-6) → C25H34O4Si

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / I₂; KOH / 20 h / 0 - 20 °C

2: LDA / tetrahydrofuran / 3 h / -78 - 20 °C

With potassium hydroxide; iodine; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2007.04.038

upstream raw materials:

(E)-3-phenylpropenal

3-cyclopentyloxy-4-methoxyphenylboronic acid

Downstream raw materials:

C₂₂H₂₆O₄

C₂₈H₃₀F₃NO₆S

R-(+)-4-(2-(3-cyclopentyloxy-4-methoxyphenyl)-2-phenylethyl)pyridine