(1R,2S)-(2-(4-(benzyloxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-(benzyloxy)benzoate)

Base Information

• Chemical Name: (1R,2S)-(2-(4-(benzyloxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-(benzyloxy)benzoate)
• CAS No.: 219603-32-4
• Molecular Formula: C₅₁H₄₃NO₈
• Molecular Weight: 797.904

Synonyms:(1R,2S)-(2-(4-(benzyloxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-(benzyloxy)benzoate)

Chemical Property of (1R,2S)-(2-(4-(benzyloxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-(benzyloxy)benzoate)

Chemical Property:

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Technology Process of (1R,2S)-(2-(4-(benzyloxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-(benzyloxy)benzoate)

There total 2 articles about (1R,2S)-(2-(4-(benzyloxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-(benzyloxy)benzoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-(benzyloxy)benzoic acid chloride (1486-50-6) + (1R,2S)-(+)-2-amino-1-phenyl-1,3-propanediol (105452-39-9) → (1R,2S)-(2-(4-(benzyloxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-(benzyloxy)benzoate) (219603-32-4)

Guidance literature:

With dmap; In pyridine; dichloromethane; at 0 - 25 ℃;

DOI:10.1021/jo981508b

Reference yield:

p-(benzyloxy)benzoic acid (1486-51-7) → (1R,2S)-(2-(4-(benzyloxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-(benzyloxy)benzoate) (219603-32-4)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / CH₂Cl₂; dimethylformamide / 3 h / 25 °C

2: 64 percent / DMAP / CH₂Cl₂; pyridine / 0 - 25 °C

With dmap; oxalyl dichloride; In pyridine; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo981508b

Reference yield: 52.0%

(1R,2S)-(2-(4-(benzyloxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-(benzyloxy)benzoate) (219603-32-4) → (1R,2S)-(2-(4-hydroxybenzamido)-1-phenyl-1,3-propanediyl)bis(4-hydoxybenzoate) (219603-31-3)

Guidance literature:

With hydrogen; W-2 Raney Ni; In methanol; ethyl acetate; for 18h; under 760 Torr;

DOI:10.1021/jo981508b

upstream raw materials:

4-(benzyloxy)benzoic acid chloride

(1R,2S)-(+)-2-amino-1-phenyl-1,3-propanediol

p-(benzyloxy)benzoic acid

Downstream raw materials:

(1R,2S)-(2-(4-hydroxybenzamido)-1-phenyl-1,3-propanediyl)bis(4-hydoxybenzoate)

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