1-<oxy>-22-<(tert-butyldimethylsilyl)oxy>docosane

Base Information

• Chemical Name: 1-<oxy>-22-<(tert-butyldimethylsilyl)oxy>docosane
• CAS No.: 170380-52-6
• Molecular Formula: C₃₇H₇₀BrO₅PSi
• Molecular Weight: 733.923
• Mol file: 170380-52-6.mol

Synonyms:1-<oxy>-22-<(tert-butyldimethylsilyl)oxy>docosane

Chemical Property of 1-<oxy>-22-<(tert-butyldimethylsilyl)oxy>docosane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-<oxy>-22-<(tert-butyldimethylsilyl)oxy>docosane

There total 3 articles about 1-<oxy>-22-<(tert-butyldimethylsilyl)oxy>docosane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

docosane-1,22-diol (22513-81-1) → 1-<oxy>-22-<(tert-butyldimethylsilyl)oxy>docosane (170380-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 46.7 percent / imidazole / dimethylformamide / 24 h / 60 - 65 °C

2: 1.) Et₃N / 1.) ether, room temperature, 16 h, 2.) 24 h

With 1H-imidazole; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jo00126a066

Reference yield:

docosanedioic acid (505-56-6) → 1-<oxy>-22-<(tert-butyldimethylsilyl)oxy>docosane (170380-52-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) BH₃*THF, 2.) 2 M NaOH, 30percent aq. H₂O₂ / 1.) THF, 2 deg C, 0.5 h; 2 to 45 deg C, 3 h, 2.) 0.5 h

2: 46.7 percent / imidazole / dimethylformamide / 24 h / 60 - 65 °C

3: 1.) Et₃N / 1.) ether, room temperature, 16 h, 2.) 24 h

With 1H-imidazole; sodium hydroxide; borane-THF; dihydrogen peroxide; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jo00126a066

Reference yield:

2-bromoethylphosphoric acid dichloride (4167-02-6) + 1-<(tert-butyldimethylsilyl)oxy>-22-docosanol (170380-51-5) + benzyl alcohol (100-51-6,185532-71-2) → 1-<oxy>-22-<(tert-butyldimethylsilyl)oxy>docosane (170380-52-6)

Guidance literature:

With triethylamine; Yield given. Multistep reaction; 1.) ether, room temperature, 16 h, 2.) 24 h;

DOI:10.1021/jo00126a066

upstream raw materials:

2-bromoethylphosphoric acid dichloride

1-<(tert-butyldimethylsilyl)oxy>-22-docosanol

benzyl alcohol

docosane-1,22-diol

Downstream raw materials:

22-<oxy>docosan-1-ol

1,22-bis<oxy>docosane