1-[4-(2-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}ethyl)phenyl]-3-phenylurea

Base Information

Chemical Name:1-[4-(2-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}ethyl)phenyl]-3-phenylurea
CAS No.:1220105-17-8
Molecular Formula:C₂₆H₂₆ClN₅O₂
Molecular Weight:475.978
Hs Code.:

Synonyms:1-[4-(2-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}ethyl)phenyl]-3-phenylurea

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Chemical Property of 1-[4-(2-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}ethyl)phenyl]-3-phenylurea

Chemical Property:

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Technology Process of 1-[4-(2-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}ethyl)phenyl]-3-phenylurea

There total 3 articles about 1-[4-(2-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}ethyl)phenyl]-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1220105-88-3
N-[2-(4-aminophenyl)ethyl]-7-(3-chloropropoxy)quinazolin-4-amine

: 103-71-9
phenyl isocyanate

: 1220105-17-8
1-[4-(2-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}ethyl)phenyl]-3-phenylurea

Guidance literature:: In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 557770-90-8
4-chloro-7-(3-chloropropoxy)quinazoline

: 1220105-17-8
1-[4-(2-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}ethyl)phenyl]-3-phenylurea

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / 1 h / Inert atmosphere; Reflux

2: dichloromethane; methanol / 20 °C / Inert atmosphere

With triethylamine; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2021.113673

Reference yield:

: 13472-00-9
p-Aminophenethylamine

: 1220105-17-8
1-[4-(2-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}ethyl)phenyl]-3-phenylurea

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / 1 h / Inert atmosphere; Reflux

2: dichloromethane; methanol / 20 °C / Inert atmosphere

With triethylamine; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2021.113673