1-{4-[2-({7-[3-(dimethylamino)propoxy]quinazolin-4-yl}amino)ethyl]phenyl}-3-phenylurea

Base Information

• Chemical Name: 1-{4-[2-({7-[3-(dimethylamino)propoxy]quinazolin-4-yl}amino)ethyl]phenyl}-3-phenylurea
• CAS No.: 1220105-15-6
• Molecular Formula: C₂₈H₃₂N₆O₂
• Molecular Weight: 484.601

Synonyms:1-{4-[2-({7-[3-(dimethylamino)propoxy]quinazolin-4-yl}amino)ethyl]phenyl}-3-phenylurea

Chemical Property of 1-{4-[2-({7-[3-(dimethylamino)propoxy]quinazolin-4-yl}amino)ethyl]phenyl}-3-phenylurea

Chemical Property:

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Technology Process of 1-{4-[2-({7-[3-(dimethylamino)propoxy]quinazolin-4-yl}amino)ethyl]phenyl}-3-phenylurea

There total 4 articles about 1-{4-[2-({7-[3-(dimethylamino)propoxy]quinazolin-4-yl}amino)ethyl]phenyl}-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1-[4-(2-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}ethyl)phenyl]-3-phenylurea (1220105-17-8) + dimethyl amine (124-40-3) → 1-{4-[2-({7-[3-(dimethylamino)propoxy]quinazolin-4-yl}amino)ethyl]phenyl}-3-phenylurea (1220105-15-6)

Guidance literature:

In N,N-dimethyl acetamide; water; at 120 ℃; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.ejmech.2021.113673

Reference yield:

4-chloro-7-(3-chloropropoxy)quinazoline (557770-90-8) → 1-{4-[2-({7-[3-(dimethylamino)propoxy]quinazolin-4-yl}amino)ethyl]phenyl}-3-phenylurea (1220105-15-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / ethanol / 1 h / Inert atmosphere; Reflux

2: dichloromethane; methanol / 20 °C / Inert atmosphere

3: N,N-dimethyl acetamide; water / 120 °C / Inert atmosphere; Microwave irradiation

With triethylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; water;

DOI:10.1016/j.ejmech.2021.113673

Reference yield:

p-Aminophenethylamine (13472-00-9) → 1-{4-[2-({7-[3-(dimethylamino)propoxy]quinazolin-4-yl}amino)ethyl]phenyl}-3-phenylurea (1220105-15-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / ethanol / 1 h / Inert atmosphere; Reflux

2: dichloromethane; methanol / 20 °C / Inert atmosphere

3: N,N-dimethyl acetamide; water / 120 °C / Inert atmosphere; Microwave irradiation

With triethylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; water;

DOI:10.1016/j.ejmech.2021.113673

upstream raw materials:

1-[4-(2-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}ethyl)phenyl]-3-phenylurea

dimethyl amine

4-chloro-7-(3-chloropropoxy)quinazoline

N-[2-(4-aminophenyl)ethyl]-7-(3-chloropropoxy)quinazolin-4-amine

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