1-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]-3-phenyl-piperidine hydrochloride

Base Information

• Chemical Name: 1-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]-3-phenyl-piperidine hydrochloride
• CAS No.: 1262193-88-3
• Molecular Formula: C₂₇H₃₂N₆O*ClH
• Molecular Weight: 493.052
• Mol file: 1262193-88-3.mol

Synonyms:1-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]-3-phenyl-piperidine hydrochloride

Chemical Property of 1-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]-3-phenyl-piperidine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]-3-phenyl-piperidine hydrochloride

There total 4 articles about 1-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]-3-phenyl-piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

1-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazole (870838-56-5) + C16H21BrN4 (1262197-86-3) → 1-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]-3-phenyl-piperidine hydrochloride (1262193-88-3)

Guidance literature:

1-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazole; With potassium acetate; bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 120 ℃; for 0.5h; Microwave irradiation;

C₁₆H₂₁BrN₄; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

1-fluoro-2-methoxy-4-nitrobenzene (454-16-0) → 1-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]-3-phenyl-piperidine hydrochloride (1262193-88-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 16 h / 125 °C / Inert atmosphere; Autoclave

2.1: hydrogen; thiophene / palladium 10% on activated carbon / methanol / 50 °C

3.1: sodium nitrite; sulfuric acid; acetic acid / 0.5 h / 10 - 20 °C

3.2: 1 h / 20 °C

4.1: bis(pinacol)diborane; potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 0.5 h / 120 °C / Microwave irradiation

4.2: 1 h / 150 °C / Microwave irradiation

With thiophene; sulfuric acid; hydrogen; potassium acetate; potassium carbonate; acetic acid; bis(pinacol)diborane; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 4.2: Suzuki-Miyaura Coupling;

Reference yield:

1-(2-methoxy-4-nitrophenyl)-4-methyl-1H-imidazole (958245-17-5) → 1-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]-3-phenyl-piperidine hydrochloride (1262193-88-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen; thiophene / palladium 10% on activated carbon / methanol / 50 °C

2.1: sodium nitrite; sulfuric acid; acetic acid / 0.5 h / 10 - 20 °C

2.2: 1 h / 20 °C

3.1: bis(pinacol)diborane; potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 0.5 h / 120 °C / Microwave irradiation

3.2: 1 h / 150 °C / Microwave irradiation

With thiophene; sulfuric acid; hydrogen; potassium acetate; acetic acid; bis(pinacol)diborane; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide; 3.2: Suzuki-Miyaura Coupling;

upstream raw materials:

1-fluoro-2-methoxy-4-nitrobenzene

1-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazole

C₁₆H₂₁BrN₄

1-(2-methoxy-4-nitrophenyl)-4-methyl-1H-imidazole

Refernces