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1-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]-3-phenyl-piperidine hydrochloride

Base Information Edit
  • Chemical Name:1-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]-3-phenyl-piperidine hydrochloride
  • CAS No.:1262193-88-3
  • Molecular Formula:C27H32N6O*ClH
  • Molecular Weight:493.052
  • Hs Code.:
  • Mol file:1262193-88-3.mol
1-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]-3-phenyl-piperidine hydrochloride

Synonyms:1-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]-3-phenyl-piperidine hydrochloride

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Chemical Property of 1-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]-3-phenyl-piperidine hydrochloride Edit
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Technology Process of 1-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]-3-phenyl-piperidine hydrochloride

There total 4 articles about 1-[3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]-3-phenyl-piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
1-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazole; With potassium acetate; bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 120 ℃; for 0.5h; Microwave irradiation;
C16H21BrN4; With potassium carbonate; tetrakis(triphenylphosphine) palladium(0); In N,N-dimethyl-formamide; at 150 ℃; for 1h; Microwave irradiation;
Guidance literature:
Multi-step reaction with 4 steps
1.1: potassium carbonate / dimethyl sulfoxide / 16 h / 125 °C / Inert atmosphere; Autoclave
2.1: hydrogen; thiophene / palladium 10% on activated carbon / methanol / 50 °C
3.1: sodium nitrite; sulfuric acid; acetic acid / 0.5 h / 10 - 20 °C
3.2: 1 h / 20 °C
4.1: bis(pinacol)diborane; potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 0.5 h / 120 °C / Microwave irradiation
4.2: 1 h / 150 °C / Microwave irradiation
With thiophene; sulfuric acid; hydrogen; potassium acetate; potassium carbonate; acetic acid; bis(pinacol)diborane; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 4.2: Suzuki-Miyaura Coupling;
Guidance literature:
Multi-step reaction with 3 steps
1.1: hydrogen; thiophene / palladium 10% on activated carbon / methanol / 50 °C
2.1: sodium nitrite; sulfuric acid; acetic acid / 0.5 h / 10 - 20 °C
2.2: 1 h / 20 °C
3.1: bis(pinacol)diborane; potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 0.5 h / 120 °C / Microwave irradiation
3.2: 1 h / 150 °C / Microwave irradiation
With thiophene; sulfuric acid; hydrogen; potassium acetate; acetic acid; bis(pinacol)diborane; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide; 3.2: Suzuki-Miyaura Coupling;
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