1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-proline

Base Information

Chemical Name:1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-proline
CAS No.:1422064-21-8
Molecular Formula:C₂₃H₃₂N₂O₇
Molecular Weight:448.516
Hs Code.:

Synonyms:1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-proline

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Chemical Property of 1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-proline

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Technology Process of 1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-proline

There total 5 articles about 1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1422064-20-7
methyl 1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-prolinate

: 1422064-21-8
1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-proline

Guidance literature:: With water; sodium hydroxide; In methanol; at 20 ℃;
DOI:10.3390/molecules18010050

Reference yield:

: 4931-66-2
methyl (S)-pyroglutamate

: 1422064-21-8
1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-proline

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran; paraffin oil / 24.25 h / 0 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

3: diethylazodicarboxylate; triphenylphosphine / toluene / 15 h / Reflux; Inert atmosphere

4: sodium hydroxide; water / methanol / 20 °C

With palladium 10% on activated carbon; water; hydrogen; sodium hydride; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; toluene; paraffin oil;
DOI:10.3390/molecules18010050

Reference yield:

: 5544-60-5
4-(benzyloxy)benzyl bromide

: 1422064-21-8
1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-proline

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran; paraffin oil / 24.25 h / 0 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

3: diethylazodicarboxylate; triphenylphosphine / toluene / 15 h / Reflux; Inert atmosphere

4: sodium hydroxide; water / methanol / 20 °C

With palladium 10% on activated carbon; water; hydrogen; sodium hydride; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; toluene; paraffin oil;
DOI:10.3390/molecules18010050