methyl 1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-prolinate

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Chemical Name:methyl 1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-prolinate
CAS No.:1422064-20-7
Molecular Formula:C₂₄H₃₄N₂O₇
Molecular Weight:462.543
Hs Code.:

Synonyms:methyl 1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-prolinate

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Chemical Property of methyl 1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-prolinate

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Technology Process of methyl 1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-prolinate

There total 4 articles about methyl 1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-prolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1422064-19-4
methyl 1-(4-hydroxybenzyl)-5-oxo-L-prolinate

: 108149-63-9
4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

: 1422064-20-7
methyl 1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-prolinate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In toluene; for 15h; Reflux; Inert atmosphere;
DOI:10.3390/molecules18010050

Reference yield:

: 4931-66-2
methyl (S)-pyroglutamate

: 1422064-20-7
methyl 1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-prolinate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran; paraffin oil / 24.25 h / 0 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

3: diethylazodicarboxylate; triphenylphosphine / toluene / 15 h / Reflux; Inert atmosphere

With palladium 10% on activated carbon; hydrogen; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; toluene; paraffin oil;
DOI:10.3390/molecules18010050

Reference yield:

: 5544-60-5
4-(benzyloxy)benzyl bromide

: 1422064-20-7
methyl 1-(4-{[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]methoxy}benzyl)-5-oxo-L-prolinate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran; paraffin oil / 24.25 h / 0 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

3: diethylazodicarboxylate; triphenylphosphine / toluene / 15 h / Reflux; Inert atmosphere

With palladium 10% on activated carbon; hydrogen; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; toluene; paraffin oil;
DOI:10.3390/molecules18010050