6-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]-triazol-4-ylmethoxy]-nicotinic acid

Base Information

Chemical Name:6-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]-triazol-4-ylmethoxy]-nicotinic acid
CAS No.:1374672-83-9
Molecular Formula:C₁₆H₁₃FN₄O₃
Molecular Weight:328.303
Hs Code.:

Synonyms:6-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]-triazol-4-ylmethoxy]-nicotinic acid

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Chemical Property of 6-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]-triazol-4-ylmethoxy]-nicotinic acid

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Technology Process of 6-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]-triazol-4-ylmethoxy]-nicotinic acid

There total 5 articles about 6-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]-triazol-4-ylmethoxy]-nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374645-64-3
[5-(4-fluoro-phenyl)-3-trimethylsilanylmethyl-3H-[1,2,3]triazol-4-yl]-methanol

: 1374672-83-9
6-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]-triazol-4-ylmethoxy]-nicotinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: water; tetrabutyl ammonium fluoride / tetrahydrofuran / 15 h / 0 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 16.5 h / 0 - 20 °C

3: water; methanol; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 20 °C

With methanol; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; sodium hydride; In tetrahydrofuran; mineral oil;

Reference yield:

: 1374645-65-4
[4-(4-fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl]methanol

: 1374672-83-9
6-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]-triazol-4-ylmethoxy]-nicotinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 16.5 h / 0 - 20 °C

2: water; methanol; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 20 °C

With methanol; lithium hydroxide monohydrate; water; sodium hydride; In tetrahydrofuran; mineral oil;

Reference yield:

: 1736-31-8
ethyl 3-(4-fluorophenyl)propiolate

: 1374672-83-9
6-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]-triazol-4-ylmethoxy]-nicotinic acid

Guidance literature:: Multi-step reaction with 5 steps

1: benzene / 77 h / Reflux; Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

3: water; tetrabutyl ammonium fluoride / tetrahydrofuran / 15 h / 0 °C

4: sodium hydride / tetrahydrofuran; mineral oil / 16.5 h / 0 - 20 °C

5: water; methanol; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 20 °C

With methanol; lithium aluminium tetrahydride; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; sodium hydride; In tetrahydrofuran; mineral oil; benzene;