1736-31-8

Basic information

• Product Name: (4-FLUORO-PHENYL)-PROPYNOIC ACID ETHYL ESTER
• Synonyms: (4-FLUORO-PHENYL)-PROPYNOIC ACID ETHYL ESTER;2-Propynoic acid, 3-(4-fluorophenyl)-, ethyl ester;ETHYL 3-(4-FLUOROPHENYL)PROPIOLATE
• CAS NO: 1736-31-8
• Molecular Formula: C₁₁H₉FO₂
• Molecular Weight: 192.19
• Mol File: 1736-31-8.mol
• Article Data: 39

Chemical Properties

• Boiling Point: 261.3°C at 760 mmHg
• Flash Point: 108.5°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 0.0116mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: (4-FLUORO-PHENYL)-PROPYNOIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (4-FLUORO-PHENYL)-PROPYNOIC ACID ETHYL ESTER(1736-31-8)
• EPA Substance Registry System: (4-FLUORO-PHENYL)-PROPYNOIC ACID ETHYL ESTER(1736-31-8)

Safety Data

• Hazardous Substances Data: 1736-31-8(Hazardous Substances Data)

Usage

General Description

(4-Fluoro-phenyl)-propynoic acid ethyl ester is a chemical compound that belongs to the ester group. The compound consists of a propynoic acid core with an ethyl ester functional group attached to it. The presence of a fluorine atom in the phenyl ring provides unique properties to the compound, making it useful in various chemical processes and research applications. It is commonly used in pharmaceutical and agrochemical industries for the synthesis of novel compounds with potential biological activities. Additionally, it is utilized in the production of specialty chemicals and as a building block in organic chemistry synthesis. The compound's properties and versatility make it a valuable component in various chemical and industrial processes.

InChI:InChI=1/C11H9FO2/c1-2-14-11(13)8-5-9-3-6-10(12)7-4-9/h3-4,6-7H,2H2,1H3

Upstream product

• 24393-52-0 ethyl (E)-3-(4-chlorophenyl)prop-2-enoate 
• 42122-47-4 2,3-dibromo-3-(4-fluoro-phenyl)-propionic acid ethyl ester 
• 136265-10-6 ethyl 4-fluorocinnamate 
• 352-34-1 4-fluoro-1-iodobenzene 
• 623-47-2 propynoic acid ethyl ester 
• 1765-93-1 4-fluoroboronic acid 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 541-41-3 chloroformic acid ethyl ester 
• 1999-00-4 ethyl 3-(4'-fluorophenyl)-3-oxopropionate 
• 403-43-0 4-fluorobenzoyl chloride 
• 456-22-4 4-Fluorobenzoic acid 
• 7681-65-4 copper(l) iodide 
• 130995-12-9 1-(4-fluorophenyl)-2-trimethylsilylacetylene 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 1004795-05-4 ethyl (E)-3-(4-fluorophenyl)-3-fluoromethylsulfonyloxy-2-propenoate 
• 1215107-18-8 ethyl 5-(benzyloxy)-6-(N-(tert-butoxycarbonyl)methylsulfonamido)-2-(4-fluorophenyl)pyrazolo[1,5-a] pyridine-3-carboxylate 
• 1229320-46-0 1-(2-chloro-3-5-dimethoxyphenyl)-6-(4-fluorophenyl)-3-methyl-2-(2,4,6-trifluorophenyl)-4-(1H)-pyridinone 
• 1374645-64-3 [5-(4-fluoro-phenyl)-3-trimethylsilanylmethyl-3H-[1,2,3]triazol-4-yl]-methanol 
• 1374645-65-4 [4-(4-fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl]methanol 
• 1374645-52-9 3-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]-triazol-4-ylmethoxy]-isoxazole-5-carboxylic acid (tetrahydro-pyran-4-yl)-amide 
• 1374645-53-0 5-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (tetrahydro-pyran-4-yl)-amide 
• 1374645-66-5 Methyl 3-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]-triazol-4-ylmethoxy]-isoxazole-5-carboxylate 
• 1374645-67-6 3-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-isoxazole-5-carboxylic acid 
• 1374645-68-7 Methyl 5-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylate 
• 1374645-69-8 5-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid 
• 1378869-09-0 6-(N-(4-bromo-3-methylbenzyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide 
• 1378869-10-3 5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-(N-(3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)methylsulfonamido)pyrazolo[1,5-a]pyridine-3-carboxamide 
• 1378868-41-7 (4-((N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-6-yl)methylsulfonamido)methyl)-2-methylphenyl)boronic acid 

Relevant articles and documents

Three-component domino process for the pyrrolizine skeleton via [3 + 2]-cycloaddition-enamine cyclization triggered by a gold catalyst

Pyrrolizines are bicyclic fused azaheterocycles with a bridgehead nitrogen contained in a core skeleton and are often found in biologically active compounds. Despite their importance, there have been few reports on concise and flexible syntheses of pyrrolizines. A novel one-pot, convergent method is described for pyrrolizines by simple mixing of iminoesters, acetylenes, and dipolarophiles in the presence of a cationic gold catalyst and an acid additive. This domino process affords multisubstituted pyrrolizines without handling unstable intermediates.

Copper-catalyzed enantioselective conjugate reduction of α,β-unsaturated esters with chiral phenol–carbene ligands

A chiral phenol–NHC ligand enabled the copper-catalyzed enantioselective conjugate reduction of α,β-unsaturated esters. The phenol moiety of the chiral NHC ligand played a critical role in producing the enantiomerically enriched products. The catalyst worked well for various (Z)-isomer substrates. Opposite enantiomers were obtained from (Z)- and (E)-isomers, with a higher enantiomeric excess from the (Z)-isomer.

Metal-Free Oxidative [5+1] Cyclization of 1,5-Enynes for the Synthesis of Pyrazine 1-Oxide

A chemo-selective nitrosylation of 1,5-enynes via a sequence of NO radical incorporation and intramolecular radical cyclization was reported. The formation of two C?N bonds and one C?O bond make this [5+1] cycloaddition reaction an efficient approach to synthesize pyrazine 1-oxides in moderate to good yields. Metal-free, short reaction time and mild conditions render this strategy more practical, eco-friendly and convenient. Synthetic utility of this protocol is highlighted by scaffolds diversification. (Figure presented.).