6-[5-(4-fluorophenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-N-(tetrahydropyran-4-yl)-nicotinamide

Base Information

Chemical Name:6-[5-(4-fluorophenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-N-(tetrahydropyran-4-yl)-nicotinamide
CAS No.:1374672-04-4
Molecular Formula:C₂₁H₂₂FN₅O₃
Molecular Weight:411.436
Hs Code.:

Synonyms:6-[5-(4-fluorophenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-N-(tetrahydropyran-4-yl)-nicotinamide

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Chemical Property of 6-[5-(4-fluorophenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-N-(tetrahydropyran-4-yl)-nicotinamide

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Technology Process of 6-[5-(4-fluorophenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-N-(tetrahydropyran-4-yl)-nicotinamide

There total 7 articles about 6-[5-(4-fluorophenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-N-(tetrahydropyran-4-yl)-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 38041-19-9
4-aminotetrahydropyran

: 1374672-83-9
6-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]-triazol-4-ylmethoxy]-nicotinic acid

: 1374672-04-4
6-[5-(4-fluorophenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-N-(tetrahydropyran-4-yl)-nicotinamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1736-31-8
ethyl 3-(4-fluorophenyl)propiolate

: 1374672-04-4
6-[5-(4-fluorophenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-N-(tetrahydropyran-4-yl)-nicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1: benzene / 77 h / Reflux; Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

3: water; tetrabutyl ammonium fluoride / tetrahydrofuran / 15 h / 0 °C

4: sodium hydride / tetrahydrofuran; mineral oil / 16.5 h / 0 - 20 °C

5: water; methanol; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

With methanol; lithium aluminium tetrahydride; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; benzene;

Reference yield:

: 1999-00-4
ethyl 3-(4'-fluorophenyl)-3-oxopropionate

: 1374672-04-4
6-[5-(4-fluorophenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-N-(tetrahydropyran-4-yl)-nicotinamide

Guidance literature:: Multi-step reaction with 7 steps

1: trifluoromethylsulfonic anhydride; triethylamine; Triphenylphosphine oxide / 1,2-dichloro-ethane / 2.5 h / 0 °C / Reflux

2: benzene / 77 h / Reflux; Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

4: water; tetrabutyl ammonium fluoride / tetrahydrofuran / 15 h / 0 °C

5: sodium hydride / tetrahydrofuran; mineral oil / 16.5 h / 0 - 20 °C

6: water; methanol; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 20 °C

7: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

With methanol; lithium aluminium tetrahydride; trifluoromethylsulfonic anhydride; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; Triphenylphosphine oxide; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil; benzene;