[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid

Base Information

Chemical Name:[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid
CAS No.:203806-00-2
Molecular Formula:C₂₁H₂₃N₂O₆P
Molecular Weight:430.397
Hs Code.:

Synonyms:[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid

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Chemical Property of [1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid

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Technology Process of [1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid

There total 6 articles about [1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 128677-62-3
5-Phthalimido-1-aminopentylphosphinic acid

: 501-53-1,94274-21-2
benzyl chloroformate

: 203806-00-2
[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 0 ℃; for 4h;
DOI:10.1039/a704097k

Reference yield:

: 85-44-9
phthalic anhydride

: 203806-00-2
[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / toluene / Heating

2: 1.) Me₂SO, (COCl)2, 2.) Et₃N / 1.) -78 deg C

3: 36 percent / H₃PO₂ / aq. ethanol / 80 °C

4: 85 percent / CF₃COOH / 1 h / Heating

5: 100 percent / aq. NaOH / dioxane / 4 h / 0 °C

With sodium hydroxide; oxalyl dichloride; hypophosphorous acid; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In 1,4-dioxane; ethanol; toluene;
DOI:10.1039/a704097k

Reference yield:

: 2508-29-4
5-hydroxypentylamine

: 203806-00-2
[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphinic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / toluene / Heating

2: 1.) Me₂SO, (COCl)2, 2.) Et₃N / 1.) -78 deg C

3: 36 percent / H₃PO₂ / aq. ethanol / 80 °C

4: 85 percent / CF₃COOH / 1 h / Heating

5: 100 percent / aq. NaOH / dioxane / 4 h / 0 °C

With sodium hydroxide; oxalyl dichloride; hypophosphorous acid; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In 1,4-dioxane; ethanol; toluene;
DOI:10.1039/a704097k