5-<2'-(cyanobiphenyl-4-yl)methyl>-2-methyl-4-methylthio-6-n-propylpyrimidine

Base Information

Chemical Name:5-<2'-(cyanobiphenyl-4-yl)methyl>-2-methyl-4-methylthio-6-n-propylpyrimidine
CAS No.:169772-86-5
Molecular Formula:C₂₃H₂₃N₃S
Molecular Weight:373.522
Hs Code.:

Synonyms:5-<2'-(cyanobiphenyl-4-yl)methyl>-2-methyl-4-methylthio-6-n-propylpyrimidine

Suppliers and Price of 5-<2'-(cyanobiphenyl-4-yl)methyl>-2-methyl-4-methylthio-6-n-propylpyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-<2'-(cyanobiphenyl-4-yl)methyl>-2-methyl-4-methylthio-6-n-propylpyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-<2'-(cyanobiphenyl-4-yl)methyl>-2-methyl-4-methylthio-6-n-propylpyrimidine

There total 6 articles about 5-<2'-(cyanobiphenyl-4-yl)methyl>-2-methyl-4-methylthio-6-n-propylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 169772-85-4
5-<2'-(cyanobiphenyl-4-yl)methyl>-4-mercapto-2-methyl-6-n-propyl pyrimidine

: 74-88-4
methyl iodide

: 169772-86-5
5-<2'-(cyanobiphenyl-4-yl)methyl>-2-methyl-4-methylthio-6-n-propylpyrimidine

Guidance literature:: With potassium carbonate; In acetone; for 3h; Heating;
DOI:10.1016/0223-5234(96)88246-8

Reference yield:

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 169772-86-5
5-<2'-(cyanobiphenyl-4-yl)methyl>-2-methyl-4-methylthio-6-n-propylpyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-diisopropylethylamine, LiCl / tetrahydrofuran / 15 h / Heating

2: 1.) NaOMe / 1.) MeOH, RT, 15 min, 2.) MeOH, a) 20 h RT, b) reflux, 3 h

3: 98 percent / POCl₃ / 6 h / 100 °C

4: 1.) conc. HCl, 2.) aq. KOH / 1.) acetone, reflux, 6 h

5: 80 percent / K₂CO₃ / acetone / 3 h / Heating

With hydrogenchloride; potassium hydroxide; sodium methylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium chloride; trichlorophosphate; In tetrahydrofuran; acetone;
DOI:10.1016/0223-5234(96)88246-8

Reference yield:

: 3249-68-1
ethyl butyroyl acetate

: 169772-86-5
5-<2'-(cyanobiphenyl-4-yl)methyl>-2-methyl-4-methylthio-6-n-propylpyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-diisopropylethylamine, LiCl / tetrahydrofuran / 15 h / Heating

2: 1.) NaOMe / 1.) MeOH, RT, 15 min, 2.) MeOH, a) 20 h RT, b) reflux, 3 h

3: 98 percent / POCl₃ / 6 h / 100 °C

4: 1.) conc. HCl, 2.) aq. KOH / 1.) acetone, reflux, 6 h

5: 80 percent / K₂CO₃ / acetone / 3 h / Heating

With hydrogenchloride; potassium hydroxide; sodium methylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium chloride; trichlorophosphate; In tetrahydrofuran; acetone;
DOI:10.1016/0223-5234(96)88246-8