{2-[(S)-1-(2-{2-[(S)-1-(2-Benzyloxy-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-acetic acid tert-butyl ester

Base Information

Chemical Name:{2-[(S)-1-(2-{2-[(S)-1-(2-Benzyloxy-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-acetic acid tert-butyl ester
CAS No.:199448-95-8
Molecular Formula:C₃₃H₅₈O₉
Molecular Weight:598.818
Hs Code.:

Synonyms:{2-[(S)-1-(2-{2-[(S)-1-(2-Benzyloxy-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-acetic acid tert-butyl ester

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Chemical Property of {2-[(S)-1-(2-{2-[(S)-1-(2-Benzyloxy-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-acetic acid tert-butyl ester

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Technology Process of {2-[(S)-1-(2-{2-[(S)-1-(2-Benzyloxy-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-acetic acid tert-butyl ester

There total 14 articles about {2-[(S)-1-(2-{2-[(S)-1-(2-Benzyloxy-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 199448-93-6
2-[(S)-1-(2-{2-[(S)-1-(2-Benzyloxy-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-ethoxymethyl)-3-methyl-butoxy]-ethanol

: 199448-95-8
{2-[(S)-1-(2-{2-[(S)-1-(2-Benzyloxy-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-acetic acid tert-butyl ester

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol;
DOI:10.1002/anie.199701221

Reference yield:

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 199448-95-8
{2-[(S)-1-(2-{2-[(S)-1-(2-Benzyloxy-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 54 percent / aq. NaNO₂, H₂SO₄

2: 75 percent / HCl / toluene

3: 87 percent / TsOH / diethyl ether

4: 94 percent / LiAlH₄ / diethyl ether

5: KOH / tetrahydrofuran

6: TsOH / methanol

7: KOH / tetrahydrofuran

8: TsOH / methanol

9: 90 percent / pyridine

10: 68 percent / KOH / tetrahydrofuran

11: 44 percent / ZnBr₂ / CH₂Cl₂

12: 85 percent / t-BuOK / 2-methyl-propan-2-ol

With pyridine; hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; sulfuric acid; potassium tert-butylate; toluene-4-sulfonic acid; zinc dibromide; sodium nitrite; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1002/anie.199701221

Reference yield:

: 13748-90-8,498-36-2
(S)-2-hydroxyl-3,3-dimethylbutyric acid

: 199448-95-8
{2-[(S)-1-(2-{2-[(S)-1-(2-Benzyloxy-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-ethoxymethyl)-3-methyl-butoxy]-ethoxy}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 75 percent / HCl / toluene

2: 87 percent / TsOH / diethyl ether

3: 94 percent / LiAlH₄ / diethyl ether

4: KOH / tetrahydrofuran

5: TsOH / methanol

6: KOH / tetrahydrofuran

7: TsOH / methanol

8: 90 percent / pyridine

9: 68 percent / KOH / tetrahydrofuran

10: 44 percent / ZnBr₂ / CH₂Cl₂

11: 85 percent / t-BuOK / 2-methyl-propan-2-ol

With pyridine; hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; potassium tert-butylate; toluene-4-sulfonic acid; zinc dibromide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1002/anie.199701221