4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid ethyl ester

Base Information

Chemical Name:4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid ethyl ester
CAS No.:1598383-19-7
Molecular Formula:C₁₈H₂₁F₆NO₃
Molecular Weight:413.36
Hs Code.:

Synonyms:4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid ethyl ester

Suppliers and Price of 4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid ethyl ester

There total 3 articles about 4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 30914-89-7
2-(3-Trifluormethylphenyl)-1,4-tetrahydro-oxazin

: 4,4,4-trifluoro-3-formyl-butyric acid ethyl ester

: 1598383-19-7
4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid ethyl ester

Guidance literature:: 2-(3-Trifluormethylphenyl)-1,4-tetrahydro-oxazin; 4,4,4-trifluoro-3-formyl-butyric acid ethyl ester; With acetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

Reference yield:

: 25597-16-4,91600-34-9,406-10-0
ethyl 4,4,4-trifluorobut-2-enoate

: 1598383-19-7
4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N,N',N'-tetramethylguanidine / 13 h / 20 °C

2.1: potassium hydroxide / water; tetrahydrofuran / 0.62 h / Cooling with ice

2.2: 0.62 h

3.1: acetic acid / dichloromethane / 0.5 h / 20 °C

3.2: 20 °C

With acetic acid; potassium hydroxide; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 328-62-1
4,4,4-trifluoro-3-(nitromethyl)butyric acid ethyl ester

: 1598383-19-7
4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / water; tetrahydrofuran / 0.62 h / Cooling with ice

1.2: 0.62 h

2.1: acetic acid / dichloromethane / 0.5 h / 20 °C

2.2: 20 °C

With acetic acid; potassium hydroxide; In tetrahydrofuran; dichloromethane; water;