(S)-N-(4-chloro-3-fluoro-phenyl)-4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyramide

Base Information

• Chemical Name: (S)-N-(4-chloro-3-fluoro-phenyl)-4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyramide
• CAS No.: 1598382-50-3
• Molecular Formula: C₂₂H₂₀ClF₇N₂O₂
• Molecular Weight: 512.855
• Mol file: 1598382-50-3.mol

Synonyms:(S)-N-(4-chloro-3-fluoro-phenyl)-4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyramide

Chemical Property of (S)-N-(4-chloro-3-fluoro-phenyl)-4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(4-chloro-3-fluoro-phenyl)-4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyramide

There total 4 articles about (S)-N-(4-chloro-3-fluoro-phenyl)-4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethylphenyl)-morpholin-4-ylmethyl]-butyric acid (1598383-20-0) + 4-chloro-3-fluoroaniline (367-22-6) → (S)-N-(4-chloro-3-fluoro-phenyl)-4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyramide (1598382-50-3)

Guidance literature:

4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethylphenyl)-morpholin-4-ylmethyl]-butyric acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; for 2h;

4-chloro-3-fluoroaniline; With pyridine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 5h;

Reference yield:

4,4,4-trifluoro-3-formyl-butyric acid ethyl ester → (S)-N-(4-chloro-3-fluoro-phenyl)-4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyramide (1598382-50-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid / dichloromethane / 0.5 h / 20 °C

1.2: 20 °C

2.1: sodium hydroxide / ethanol / 0.42 h / Reflux; Inert atmosphere

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h

3.2: 5 h / 20 °C

With oxalyl dichloride; acetic acid; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid ethyl ester (1598383-19-7) → (S)-N-(4-chloro-3-fluoro-phenyl)-4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyramide (1598382-50-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol / 0.42 h / Reflux; Inert atmosphere

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h

2.2: 5 h / 20 °C

With oxalyl dichloride; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4,4,4-trifluoro-3-(nitromethyl)butyric acid ethyl ester

4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid ethyl ester

4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethylphenyl)-morpholin-4-ylmethyl]-butyric acid

4-chloro-3-fluoroaniline