4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethylphenyl)-morpholin-4-ylmethyl]-butyric acid

Base Information

Chemical Name:4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethylphenyl)-morpholin-4-ylmethyl]-butyric acid
CAS No.:1598383-20-0
Molecular Formula:C₁₆H₁₇F₆NO₃
Molecular Weight:385.306
Hs Code.:

Synonyms:4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethylphenyl)-morpholin-4-ylmethyl]-butyric acid

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Chemical Property of 4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethylphenyl)-morpholin-4-ylmethyl]-butyric acid

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Technology Process of 4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethylphenyl)-morpholin-4-ylmethyl]-butyric acid

There total 2 articles about 4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethylphenyl)-morpholin-4-ylmethyl]-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1598383-19-7
4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyric acid ethyl ester

: 1598383-20-0
4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethylphenyl)-morpholin-4-ylmethyl]-butyric acid

Guidance literature:: With sodium hydroxide; In ethanol; for 0.416667h; Reflux; Inert atmosphere;

Reference yield:

: 328-62-1
4,4,4-trifluoro-3-(nitromethyl)butyric acid ethyl ester

: 1598383-20-0
4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethylphenyl)-morpholin-4-ylmethyl]-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / water; tetrahydrofuran / 0.62 h / Cooling with ice

1.2: 0.62 h

2.1: acetic acid / dichloromethane / 0.5 h / 20 °C

2.2: 20 °C

3.1: sodium hydroxide / ethanol / 0.42 h / Reflux; Inert atmosphere

With acetic acid; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield: 16.0%

: 1598383-20-0
4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethylphenyl)-morpholin-4-ylmethyl]-butyric acid

: 367-22-6
4-chloro-3-fluoroaniline

: 1598382-50-3
(S)-N-(4-chloro-3-fluoro-phenyl)-4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-butyramide

Guidance literature:: 4,4,4-trifluoro-3-[(R)-2-(3-trifluoromethylphenyl)-morpholin-4-ylmethyl]-butyric acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; for 2h;

4-chloro-3-fluoroaniline; With pyridine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 5h;