methyl trans-5,6-dihydro-6-(3,4,5-trimethoxyphenyl)cyclobuta(f)-1,3-benzodioxole-5-carboxylate

Base Information

Chemical Name:methyl trans-5,6-dihydro-6-(3,4,5-trimethoxyphenyl)cyclobuta(f)-1,3-benzodioxole-5-carboxylate
CAS No.:94706-19-1
Molecular Formula:C₂₀H₂₀O₇
Molecular Weight:372.375
Hs Code.:

Synonyms:methyl trans-5,6-dihydro-6-(3,4,5-trimethoxyphenyl)cyclobuta(f)-1,3-benzodioxole-5-carboxylate

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Chemical Property of methyl trans-5,6-dihydro-6-(3,4,5-trimethoxyphenyl)cyclobuta(f)-1,3-benzodioxole-5-carboxylate

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Technology Process of methyl trans-5,6-dihydro-6-(3,4,5-trimethoxyphenyl)cyclobuta(f)-1,3-benzodioxole-5-carboxylate

There total 8 articles about methyl trans-5,6-dihydro-6-(3,4,5-trimethoxyphenyl)cyclobuta(f)-1,3-benzodioxole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 67-56-1
methanol

: 94671-18-8
6-diazo-7-(3,4,5-trimethoxyphenyl)-5H-indeno<5,6-d>-1,3-dioxol-5-one

: 94671-09-7
6,7-dihydro-7-(3,4,5-trimethoxyphenyl)-5H-indeno<5.6-d>-1,3-dioxol-5-one

: 94706-19-1
methyl trans-5,6-dihydro-6-(3,4,5-trimethoxyphenyl)cyclobuta(f)-1,3-benzodioxole-5-carboxylate

: 94671-20-2
6,7-dihydro-6-methoxy-7-(3,4,5-trimethoxyphenyl)-5H-indeno<5,6-d>-1,3-dioxol-5-one

Guidance literature:: for 5h; Irradiation;
DOI:10.1021/jo00207a034

Reference yield: 7.0%

: 94671-18-8
6-diazo-7-(3,4,5-trimethoxyphenyl)-5H-indeno<5,6-d>-1,3-dioxol-5-one

: 94671-09-7
6,7-dihydro-7-(3,4,5-trimethoxyphenyl)-5H-indeno<5.6-d>-1,3-dioxol-5-one

: 94706-19-1
methyl trans-5,6-dihydro-6-(3,4,5-trimethoxyphenyl)cyclobuta(f)-1,3-benzodioxole-5-carboxylate

: 94671-20-2
6,7-dihydro-6-methoxy-7-(3,4,5-trimethoxyphenyl)-5H-indeno<5,6-d>-1,3-dioxol-5-one

Guidance literature:: With methanol; for 5h; Irradiation;
DOI:10.1021/jo00207a034

Reference yield:

: 3162-29-6
1-(benzo[d][1,3]dioxol-6-yl)ethanone

: 94706-19-1
methyl trans-5,6-dihydro-6-(3,4,5-trimethoxyphenyl)cyclobuta(f)-1,3-benzodioxole-5-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH, KH / 1.) THF, 66 deg C, 2.) reflux, 1 h

2: glacial acetic acid, piperidine / benzene / 19 h / Heating

3: 78 percent / AlCl₃ / CH₂Cl₂ / 1 h / 0 °C

4: 97 percent / 50percent aq. HCl / acetone / 48 h / Heating

5: 95 percent / concd. HCl, isoamyl nitrite / ethanol; CH₂Cl₂ / 0 - 25 °C

6: 72 percent / 1N KOH, concd. NH₄OH, 5percent NaOCl / 11 h / 0 - 25 °C

7: 7 percent / 5 h / Irradiation; var. solvents as reagents, var. reaction conditions

With piperidine; hydrogenchloride; potassium hydroxide; ammonium hydroxide; sodium hypochlorite; aluminium trichloride; potassium hydride; sodium hydride; acetic acid; isopentyl nitrite; In ethanol; dichloromethane; acetone; benzene;
DOI:10.1021/jo00207a034